@BohacekLab Here a more recent paper: https://t.co/GbHng534Mr No statistically significant effect of placebo vs. no treatment in depression. If patients get better, it may be the natural course of disease, regression to the mean.
2/9: 📈 Recent systematic reviews suggested greater contextual effects than the Cochrane review (https://t.co/VAPTjsmGnZ). However, these discrepancies often stem from inappropriate meta-analytical methods. #MetaAnalysis #ResearchFindings
RT @DrXaverius: @angelaesnormal @Oscar_Teix de hecho para la mayoría de cosas no lo es, si lo comparas como es debido con no tratar, se evi…
@angelaesnormal @Oscar_Teix de hecho para la mayoría de cosas no lo es, si lo comparas como es debido con no tratar, se evidencia que el 'placebo' como tal se aplica a unas pocas condiciones y el resto es regresión a la media, no un tamaño de efecto de tra
@mariusschober @FlorianDreaming 2/2 But they do *not* heal. They only have effects on a very strict set of symptoms, mostly subjective. https://t.co/I4zeIwktQ6
@marjkoren @NicolasPinsault @TIMC_Lab @FondationAPICIL Globalement on a pour données que : - les interventions placebos semblent pas faire grand chose en général https://t.co/zIaFtVQ1fn - on a des effets placebos liés à d'autres facteurs, par exemple on pe
@AnthonyMBonnet Bonjour, on peut plutôt utiliser les effets placebos plutôt que le placebo, c'est eux qui sont efficaces sur certains symptômes comme la douleur en particulier, alors que les placebos ne sont pas nécessaires et à l'efficacité bien plus disc
@ThomSkell @pam_lna @poupette80 @thelittlegirl22 @Topiramatee Pas que, le fait de voir un professionnel va déjà engendrer un soulagement pour les patients. Enfin l'effet placebo reste globalement faible sur le plan clinique. https://t.co/kUka6JFeCp
@jonathanstea @KristianGunder However, https://t.co/mOuUvcUlrh “Authors' conclusions: We did not find that placebo interventions have important clinical effects in general. However, in certain settings placebo interventions can influence patient-reported
@michaelaye @EpiEllie @zeta_globin Placebos don't provide replicated/clinically meaningful differences in 'blood test' results. https://t.co/OLphKI1ESW https://t.co/hpAMSZf4c7 As Dr Murray suggested, the study you are thinking of, most likely was inadequat
@Cobra_FX_ La MA a été maj en 2010 avec une significativité. L'étude du placebo est une discipline intéressante, et il existe des variabilités selon les outcomes étudiés (effet + important pour PRO, notamment la douleur). https://t.co/eusKqg70fw
@qsfromkevin The main thing is the Cochrane review that did a meta-analysis of a bunch of studies. They found that placebos only "work" in subjective outcome measures, and even then are dependent on survey design https://t.co/2UfCwYaeYM
@jonatanpallesen and here's a metaanalysis from 2010 by the samy guys with a bit different conclusion: https://t.co/wc6poyRNHV
@SantiMrey @marcsuroz @BestTrollEUW suele citarse para ello un meta-meta-meta anaĺisis que literalmente tiene esto en el abstract! https://t.co/L5gNLARj0w https://t.co/AFiDU59DUr
@DiscernHeal If you are using the 2001 study by Hrobjartsson and Gotzsche for this nugget of info, it’s since been revisited. https://t.co/20cO5NkrTF https://t.co/QXXcQxUlyA
@Erreur_781 @JimDoubleYou1 @Nida0131 @jaimylepaquet @Pigrette2 Les effets placebos varient en fonction de l'intervention c'est évoqué par exemple ici (et dans le fond c'est peu étonnant) : https://t.co/zIaFtVQ1fn
@yudapearl @soboleffspaces 2/2) This has often been overlooked and of course unless you are interested in placebo effects per se you don’t need such an arm. However some three armed trials with an open arm have been run & the results are interesting. h
@moreisdifferent Key reference: https://t.co/vNHKRJ9Acs
@Tjdriii This one is the go-to I’m aware of. Tbf, I am prob overstating the case of no effect. Genuine placebo effect is real but i think a lot smaller than most people assume. https://t.co/XH6CuJ0M7v
Three reviews of the evidence on placebos concluded they are largely ineffective, and variations in results arise from methodological differences between studies: "We did not find that placebo interventions have important clinical effects in general." ht
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
@francois_bzski @TroncheBiais "Les placebos ont un effet" Bof. Surtout des placebos comme des granules. L'essentiel des effets placebos ne viennent pas des placebos. https://t.co/zIaFtVQ1fn
@davidrieff Two meta-analyses with different views: fhttps://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003974.pub3/full a sceptical view & more recent, more positive view https://t.co/FkuWPhlAtF). Some more accessible reports here: https://t
@CitronAlcalin Sachant que l'effet placebo ne produit pas de miracles, on joue avec la vie des gens dans ttes les RCTs de médicaments destinés à soigner des maladies graves. Le groupe contrôle sert de faire valoir: + on y trouve de morts, + on est content
@Heretic_StatusQ @davideyoungmd @HighlandJoes @DrKatEpi @WHO @AKalcker Heretic_StatusQ wrote "... placebo ...". If a placebo is sufficient, distilled-water would suffice, rather than industrial-bleach, nominally sold by Kalcker's wife for 100x what it cos
@julien_frison @RomainBacque @jeremy_royaux @LouTheSceptic Attention aux définitions Hróbjartsson et Gøtzsche parlent du placebo en lui-même, le procédé supposé inerte, ou des interventions placebo, pas de l'effet placebo généralement. Il y a cette revue
@joaopeniche1 @taf @enfermeira_a Eh pá isso é um artigo de opinião e se tem respaldo científico não revela fonte... Já a Cochrane... https://t.co/T4djA04KGk https://t.co/XucL9cZvan
@mattyglesias https://t.co/kQcffWB1r5 is a systematic Cochrane review that finds that placebos might help with pain & nausea but have negligible effects on anything else.
@CitronAlcalin @El1seD @DarthLomig @UIAthee Ça c'est leur source : https://t.co/5onlJdI4sY Va argumenter avec eux et faire un édit sur le wiki de l'homéopathie, moi je suis pas taillée pour lire des papiers de recherche (du coup je ne sais même pas ce que
@MedCrisis Favorite fact: pre-to-post comparisons in the placebo arm do not measure the placebo effect, but a combination of regression to the mean, random measurement variation, and occasionally a true effect. You need a no treatment group. https://t.co/
@johnbluesjunior @Scintigraphiste Non. Médicalement un placebo n'a pas beaucoup plus d'effets que rien du tout, surtout pas un comprimé placebo. L'essentiel des effets placebos n'est pas dans le placebo. https://t.co/zIaFtVQ1fn Ou ce petit exemple https:
@zeynep which is the basis of so many “mind/body”-based therapies whether they admit it or not (like CBT for chronic fatigue & pain, mindfulness, “brain rewiring”, Lightning Process etc). See: https://t.co/YkEVuQbobJ or https://t.co/nBodnumEnh or ht
▪️ Il n’y avait pas d’effet placébo significatif pour les critères mesurés objectivement (paramètres mesurables ou symptômes visibles comme la « glycémie » ou « volume d’air expiré ») Source : https://t.co/t2UFunL5eM
@one_dirt @HalfHrted_Himbo @LaRodeusePale Ça faisait déjà longtemps que la revue de Hróbjartsson était passée par là par exemple https://t.co/wOxyDgaMXP Mais aussi qu'on voit que le plus important n'est pas l'intervention même pour les symptômes où les ef
RT @CitronAlcalin: Par exemple, il a été évalué que l'intervention placebo (faux médicament par exemple) en elle-même n'est pas si intéress…
Yes, most distraction-like interventions — like swearing in the blog post — may have a real, but again modest, and short-lived effect. The Cochrane review of the placebo effect agrees with this, but shows that it is otherwise just regression to the mean: h
@MarekSJF That is not what the evidence shows. There is indeed a small phenomenon where endorphins are released but it is short-term, but the placebo effect is more regression to the mean than anything else. https://t.co/YkEVuQaQmb https://t.co/0y96N4GvG
@ISlovan @ClaireDruez @fadouce @GARREAU75 Hróbjartsson y en a pas 36. C'est surtout celle-ci : https://t.co/zIaFtVQ1fn Chvetzoff ça date un peu mais pas de grosse remise en question (et comme quelqu'un a parlé de cellule cancéreuse) : https://t.co/40KQyY0
@Tjdriii Interesting. Here’s probably the most popular paper on this concern reviewing trials with a no-treatment group. I haven’t dived deeply into it, so can’t really speak as to its quality. https://t.co/XH6CuJ0M7v
A 2010 Cochrane review came to a similar conclusion. The effects were small and mainly found in patient reported metrics (ie subjective measures like pain). https://t.co/MunPUgTQWB https://t.co/qSMUTvL4Te
@BenSaul @Sebbyy78 @Bzh441 Je vois pas trop de réponse définitive dans ce que j'ai dit. Par contre vous pouvez commencer par lire ce genre d'articles, car le monde médical est déjà au courant de ce que je raconte : https://t.co/40KQyY01dC https://t.co/m9
RT @GoodluckJBers14: #CochraneDaily Is masking patients and clinicians in trials Fool's Gold? Read the commentary at https://t.co/M2C2Hc2U7…
RT @cochrane_nz: Is masking patients and clinicians in trials Fool's Gold? Read the commentary at https://t.co/arvB8lhZwE and check the @c…
RT @cochrane_nz: Is masking patients and clinicians in trials Fool's Gold? Read the commentary at https://t.co/arvB8lhZwE and check the @c…
Is masking patients and clinicians in trials Fool's Gold? Read the commentary at https://t.co/arvB8lhZwE and check the @cochranecollab review of the effects of placebo at https://t.co/wc8dHJdJtM https://t.co/8aBqAB6Cm2
RT @GoodluckJBers14: #CochraneDaily Is masking patients and clinicians in trials Fool's Gold? Read the commentary at https://t.co/M2C2Hc2U7…
RT @GoodluckJBers14: #CochraneDaily Is masking patients and clinicians in trials Fool's Gold? Read the commentary at https://t.co/M2C2Hc2U7…
RT @GoodluckJBers14: #CochraneDaily Is masking patients and clinicians in trials Fool's Gold? Read the commentary at https://t.co/M2C2Hc2U7…
#CochraneDaily Is masking patients and clinicians in trials Fool's Gold? Read the commentary at https://t.co/M2C2Hc2U7F and check the @cochranecollab review of the effects of placebo at https://t.co/OSaWOkFDiV @dfmcauley
@FerryDanini Merci pour ces précisions, en cours je cite souvent le travail du groupe Cochrane en particulier celui-ci sur l'effet placebo: https://t.co/vKkdJClfji Qu'en pensez-vous? On est d'accord que c'est robuste comme source? (Juste pour être sûr, n'
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
Also: "larger effects of placebo interventions were associated with... patient-involved outcomes (...), small trials, and trials with the explicit purpose of studying placebo." This doesn't look good 🤦♂️
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
RT @salonium: Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects ten…
Many people incorrectly believe the benefits of antidepressants are actually "placebo effects." However, placebo effects tend to be small. For depression, they are non-significant – no difference detected between receiving a placebo vs no treatment at all
@dr_musgrave A careful review of the evidence suggests that the nocebo effect as commonly proposed is a result of bad research more than a true phenomenon. Also see https://t.co/YkEVuQaQmb Your Twitter bio reads “often sceptical”. Please don’t let this f
@Sonic_urticant @sTeamTraen Le placebo doit être sûrement l’exemple numéro 1 d’effet psychosomatique. Pourtant quand on regarde de plus près… Beaucoup de méthodologie pourrie alors que c’est probablement principalement une regression à la moyenne. https:/
@netznutzniesser @literalbanana @danlistensto It's likely that a lot of what we consider 'placebo effects' are actually regression to the mean https://t.co/HlTddGxaKe Though not always - e.g. you can compare placebo vs no treatment, and sometimes placebo r
@rebeccawatson And because it’s my go-to to see if there are meta-analyses out there, here’s a 2020 Cochrane review that at a glance seems to be saying much the same thing (particularly about quality of trials). https://t.co/eCz1zQ2Umc
@markhoro @joannamoncrieff @HengartnerMP I don't understand much of this, but I'm interested in your opinion, given you previously opined that "evidence for true placebo effects (expectancy) is very limited." https://t.co/8Hr6v1xxX3
@chrisjamesdubey The evidence for true placebo effects (expectancy) is very limited... Studies that compared placebo interventions to no treatment barely find substantial and robust differences in outcome, except perhaps in highly subjective conditions suc
@Barbusceptique @futurasciences Non mais ça veut pas dire grand chose en fait. Ça dépend de ce qu'on étudie, comment on le mesure, et de plein d'autres conditions. Et vu le phénomène il n'y a pas vraiment de consensus sur l'idée que ce serait spécifique.
@billy_fdz @OSS117_Helsinki Les publications de Kaptchuk, Blease, Locher... En gros la littérature scientifique récente sur les effets placebos. Et ça : https://t.co/zIaFtVQ1fn
@MiguelRivera_01 @catnyp13 @hartl73516271 @OdiEtAmo_PRNqd @lborodach @rn_critcare I would be interested in your evidence that it has a real physiological effect, as that is contradicted by: https://t.co/WH6B3OjKnk https://t.co/aC6s7epilz https://t.co/NZ9VC
@gbutrous The literature has been telling us to rethink the importance of placebo for years! https://t.co/nzzlEe7xLZ
@lonnibesancon Ce truc m'avait revoir à la baisse l'impact du placebo que je m'imaginais https://t.co/VpUhlNBFNQ "**Larger effects of placebo*** were also found in trials that ***did not inform*** patients about the possible placebo intervention." Bémol:
Here’s the Cochrane review that concluded the placebo effect is mostly powerless👇🏻4/x https://t.co/oZi7sPghSQ
@strain_rate True, but from studies that include both a non-treatment and a placebo arm (where RTTM should apply to both), non-RTTM mediated treatment effects seem to be limited to patient reported subjective outcomes like pain and nausea https://t.co/KjQX
@AlanLevinovitz @douggreigYYC @elisaperego78 @WoollerEmma @MatthewJDalby Control arms of trials are indeed necessary. If only to account for reporting bias and natural recovery. The placebo effect is another interesting phenomenon. This Cochrane meta-ana
RT @DerekGriffin86: "We did not find that placebo interventions have important clinical effects in general." Placebos are not powerful. htt…
@Dorian99g @m0ziz @DraakBZH @MlChanteloup @Moustimi0 @Asclepios_YT Ça reste quand même très discutable et cette pratique traduit justement une méconnaissance certaine des effets placebos et contextuels qui ne dépendent ni uniquement ni nécessairement d'int
Placebo effects do not justify interventions
RT @DerekGriffin86: "We did not find that placebo interventions have important clinical effects in general." Placebos are not powerful. htt…
RT @DerekGriffin86: "We did not find that placebo interventions have important clinical effects in general." Placebos are not powerful. htt…
RT @joshlavalleeMK: #PainNerds @ldruartPT
RT @DerekGriffin86: "We did not find that placebo interventions have important clinical effects in general." Placebos are not powerful. htt…
RT @DerekGriffin86: "We did not find that placebo interventions have important clinical effects in general." Placebos are not powerful. htt…
RT @DerekGriffin86: "We did not find that placebo interventions have important clinical effects in general." Placebos are not powerful. htt…
RT @DerekGriffin86: "We did not find that placebo interventions have important clinical effects in general." Placebos are not powerful. htt…