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Cochrane Database of Systematic Reviews

Surgery for scoliosis in Duchenne muscular dystrophy

Overview of attention for article published in Cochrane database of systematic reviews, February 2013
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38 Mendeley
Surgery for scoliosis in Duchenne muscular dystrophy
Published in
Cochrane database of systematic reviews, February 2013
DOI 10.1002/14651858.cd005375.pub3
Pubmed ID

Cheuk DK, Wong V, Wraige E, Baxter P, Cole A, Cheuk, Daniel KL, Wong, Virginia, Wraige, Elizabeth, Baxter, Peter, Cole, Ashley, Cheuk, Daniel K L


Scoliosis in people with Duchenne muscular dystrophy is usually progressive and treated with surgery. However, it is unclear whether the existing evidence is sufficiently scientifically rigorous to support a recommendation for spinal surgery for most people with Duchenne muscular dystrophy and scoliosis. This is an updated review and an updated search was undertaken in which no new studies were found. To determine the effectiveness and safety of spinal surgery in people with Duchenne muscular dystrophy with scoliosis. We intended to test whether spinal surgery is effective in increasing survival, improving respiratory function, improving quality of life and overall functioning; and whether spinal surgery is associated with severe adverse effects. We searched the specialized registers of the Cochrane Neuromuscular Disease Group (31 July 2012), MEDLINE (January 1966 to July 2012), EMBASE (January 1947 to July 2012), CENTRAL (2012, Issue 7 in the Cochrane Library), CINAHL Plus(January 1937 to July 2012), Proquest Dissertation and Thesis Database (January 1980 to July 2012), and the National Institute of Health Clinical Trials Database (July 2012). No language restrictions were imposed. We planned to include controlled clinical trials using random or quasi-random allocation of treatment evaluating all forms of spinal surgery for scoliosis in people with Duchenne muscular dystrophy in the review. The control interventions would have been no treatment, non-operative treatment, or a different form of spinal surgery. Two authors independently examined the search results and evaluated the study characteristics against inclusion criteria to decide which ones would be included in the review. On searching, 47 studies were relevant but none met the inclusion criteria for the review, because they were not clinical trials but prospective or retrospective reviews of case series. Since there were no randomized controlled clinical trials available to evaluate the effectiveness of scoliosis surgery in people with Duchenne muscular dystrophy, no evidence-based recommendation can be made for clinical practice. People with scoliosis should be informed about the uncertainty of benefits and potential risks of surgery for scoliosis. Randomized controlled trials are needed to investigate the effectiveness of scoliosis surgery, in terms of quality of life, functional status, respiratory function and life expectancy.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Portugal 1 3%
Unknown 36 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 16%
Student > Master 5 13%
Student > Bachelor 4 11%
Researcher 4 11%
Other 3 8%
Other 8 21%
Unknown 8 21%
Readers by discipline Count As %
Medicine and Dentistry 16 42%
Nursing and Health Professions 5 13%
Psychology 3 8%
Engineering 2 5%
Social Sciences 2 5%
Other 3 8%
Unknown 7 18%