@RHathcock @jeffventura Here is a comprehensive review from Cochrane on statins and cardiovascular disease. Read it and tell me what you think. https://t.co/wucUOIAKSb
@saaramamdouh please read these https://t.co/oWLSjqRe96 https://t.co/4ckZBKHjVp https://t.co/ox2SNMkigR
@holmanm @emigal Science disagrees with you https://t.co/wucUOIBiHJ
@mkaeberlein @BradStanfieldMD @statto As usual, your qualified and credible reply. There are reductions in CAD in primary prevention studies. However, I believe they all studied unhealthy populations (smokers. Hypertension, Metabolic syndrome etc). Modest
I’d love to read more takes on this. It’s both in absolute and relative risk terms the same benefit as statins (and presumably additive?) https://t.co/CuLoRIDVrm(95%25
@SimmonsBart @BradCLemley No need to cherry-pick a single study. The most reputable meta-analysis on the topic shows that statins are effective in reducing fatal and non-fatal CVD events while also reducing all-cause mortality without increasing risk for s
@BradCLemley @SimmonsBart The most reputable meta-analysis shows that statins are effective in reducing fatal and no -fatal CVD events without increasing risk for serious adverse events. https://t.co/5mDb44kDj9
@erudenko > кокрановский обзор (а это высший класс исследований - https://t.co/azwJx6ifKR), дающий цифры снижения смертности на 14%, сердечно-сосудистые события - на на 27%, инсульта на 22%, при снижении ЛПНП на 1 ммоль. Что нам еще требуется для официа
RT @jkelovuori: @GrimmGreen It's just you, Tahir. By his logic, every medicine found by Cochrane to be effective and without adverse effec…
@GrimmGreen It's just you, Tahir. By his logic, every medicine found by Cochrane to be effective and without adverse effects, is because of "industry infiltration". Eg. statins: https://t.co/JK19KcqYjE Being "obsessed" with interventions for smoking c
@RFRedberg Say what?!?!?!?!?!?!? https://t.co/KGepJ016np
@Shark3736 The meta analyses are mixed w/r/t overall survival for primary prevention (ie for people with no history of CVD) Cochrane says yes but allowed trials that included up to 10% pts with prior CVD, JAMA says no https://t.co/mvkkzrG9Jq https://
@twitevit Yes. In conjunction with controlling other risk factors like smoking, diabetes, hypertension and obesity. https://t.co/Fy9xapqmcZ
@Ogerpus @DrMcFillin How do you explain away the consistent findings of reductions in mortality? https://t.co/IlpT9LTAEs
@MasalaFry69 @NutritionMadeS3 "All‐cause mortality was reduced by statins (OR 0.86); as was combined fatal and non‐fatal CVD RR 0.75, combined fatal and non‐fatal CHD events RR 0.73 and combined fatal and non‐fatal stroke (RR 0.78)". https://t.co/qjzSde0Z
@MasalaFry69 @NutritionMadeS3 If you use statin, mortality is reduced
@MasalaFry69 @NutritionMadeS3 “All‐cause mortality was reduced by statins (OR 0.86, 95% CI 0.79 to 0.94)” I would rather believe a good meta-analysis of 18 controlled studies than an epidemiological study. https://t.co/TO7pT30vGB
Here's a less anecdotal reference
Would hate to see what a high risk of bias looks like.
RT @DoctorAnarchist: Here's the study and here's the relevant quote. Does that seem credible? https://t.co/Yz8KzzykaY https://t.co/u3SCg6…
RT @DoctorAnarchist: Here's the study and here's the relevant quote. Does that seem credible? https://t.co/Yz8KzzykaY https://t.co/u3SCg6…
RT @DoctorAnarchist: Here's the study and here's the relevant quote. Does that seem credible? https://t.co/Yz8KzzykaY https://t.co/u3SCg6…
RT @DoctorAnarchist: Here's the study and here's the relevant quote. Does that seem credible? https://t.co/Yz8KzzykaY https://t.co/u3SCg6…
RT @DoctorAnarchist: Here's the study and here's the relevant quote. Does that seem credible? https://t.co/Yz8KzzykaY https://t.co/u3SCg6…
RT @DoctorAnarchist: Here's the study and here's the relevant quote. Does that seem credible? https://t.co/Yz8KzzykaY https://t.co/u3SCg6…
RT @DoctorAnarchist: Here's the study and here's the relevant quote. Does that seem credible? https://t.co/Yz8KzzykaY https://t.co/u3SCg6…
Here's the study and here's the relevant quote. Does that seem credible? https://t.co/Yz8KzzykaY https://t.co/u3SCg6OrkY
@richardbeall10 @mgtmccartney @LauraRupsis Statins - evidence of effectiveness in people who don't already have cardiovascular disease https://t.co/IlpT9LTAEs
@chrisc334 @rubin_allergy @LizHighleyman 😂 "no good evidence" https://t.co/pPVGGhWUF3
@serotavirus Statins at least have evidence that they reduce mortality, but NNT is 278 per year to prevent major CVD event. I can't unlock the article to get the NNT for mortality. https://t.co/DYSpF5Hk4R
@mellojonny Doesn't everyone who prescribes statins know the RR of CVD for primary prevention? Otherwise how could they ever inform or advise patients? Don't we all know QRisk doesn't include exercise or "eating better" & that it can't be used to predi
@fynn_fan @VPrasadMDMPH @drjohnm This says otherwise. I'm not expert though. https://t.co/ODpMNQoetb
@HodkinsonAlice @m1chaelbarnes @TomPMarshall Reduction in all cause mortality seems like good outcome to me https://t.co/T326ppXwm4 Agree with @TomPMarshall qrisk and shared decision making with https://t.co/IuH6NmM7rG or similar
@BobPfalzgraf @holmanm In case you prefer Cochrane reviews. https://t.co/vGNBPZSyG2
@raphaels7 Statins could benefit the general population. https://t.co/N5a0k0XOlG
Hola, @FITrebelde hace un tiempo hiciste un artículo sobre LDL/estatinas y mencionabas un paper que se actualizó : https://t.co/iH4FPCdnZC cambiando las conclusiones y siendo más favorable que inicialmente. Por si lo quieres actualizar https://t.co/9GtU7b0
@Lunatic__Fringe Evidence for primary prevention is there and growing: https://t.co/ejDchRVw2h
@jimmicbreeze @RWMaloneMD No doctor prescribes 80mg of “statins” 2-3 times a day. Atorvastatin may be given once a day at 80mg, and high intensity statins significantly reduces the risk of ASCVD: https://t.co/quDeNmDgGH they are safe and effective and save
@twitevit @Cypermethrin1 @christiankoeder Why do you reply then block me? That just proves you know your wrong and statins/LDL lowering reduce CV events and all-cause mortality in primary prevention: https://t.co/HD9iAGbAEB and they also restore endothelia
@CaptRockyBob @ATHjournal @HolvenKirsten @jrvl High LDL causes ASCVD. There is so much evidence: https://t.co/EG0e1BNlnw and it is pretty much impossible to know that you have 0 plaque and tests are 100 percent accurate. Lipid lowering also lowers risk of
@LDLSkeptic @KenDBerryMD @ProfTimNoakes @DrAseemMalhotra @FructoseNo @BelindaFettke @eatmostlyfatali How do you explain statins reversing and stabilizing atherosclerotic plaque?: https://t.co/3gV3qiJ0h0 and https://t.co/KI4FJbu8TI and https://t.co/lUuERzsO
@DrAseemMalhotra @DrFrankLipman @lowcarbGP @FatEmperor @zoeharcombe @ProfTimNoakes @drmarkhyman @LDLskeptic2 @DaveKeto @KenDBerryMD @bigfatsurprise Right so I should just just believe you even though you ignore 99 percent of the studies: https://t.co/EG0e1
@twitevit @christiankoeder And statins lower total mortality too: https://t.co/quDeNmDgGH and they reverse and stabilize atherosclerotic plaques: https://t.co/lUuERzsOeN Statins have also been associated with lower risk of several different cancers: https:
@DrAseemMalhotra There is convincing evidence. Here ya go: https://t.co/quDeNmDgGH and https://t.co/5YiR9y1SUU and https://t.co/Bl3WA9PAPK and https://t.co/gqzPH1WirG and literal plaque regression: https://t.co/3gV3qiJ0h0 and https://t.co/h3OQnJ3irV this i
@TimHowe73500437 @Dziner4Art @DrAseemMalhotra @FatEmperor @bigfatsurprise @zoeharcombe @ProfTimNoakes @lowcarbGP @theJeremyVine @drmarkhyman @EamonnHolmes @GurinderC @susannareid100 No cholesterol is a major risk factor for heart disease and LDL-C is one o
@allanyo66585290 @Dziner4Art @DrAseemMalhotra @FatEmperor @bigfatsurprise @zoeharcombe @ProfTimNoakes @lowcarbGP @theJeremyVine @drmarkhyman @EamonnHolmes @GurinderC @susannareid100 And so further on, if high ldl in this genetic disorder causes early cvd,
@dremilyportermd @DBelardoMD I don’t know all of your circumstances and risk factors, but regarding statins in primary prevention, yes there’s ample evidence for atherosclerotic event prevention; e.g. https://t.co/bSkbu5s2G7
@leegallyred @ShamblerSynth @BromleyBeau Interesting. Still, the 2013 Cochrane review came down broadly in favour of statin treatment for a wide group of people https://t.co/MOXq1d3atV
@zoeharcombe What do you think about the 2013 Cochran review that reported no COI with its authors? It showed in a comprehensive analysis a clear benefit of statin use to all cause mortality. https://t.co/sMHklRMRku
@rabois @MattZschwartz @Jabaluck @anthlittle What you cited was a literature review. For an actual meta-analysis on statins, Cochrane published this paper in 2013, which review 18 RCTs on statins conducted between 1994 and 2008: https://t.co/11T6oUcgV6
@CBRooooney @DBannarMartin @JennyWeyman @DrAseemMalhotra @MattHancock Not my field and obviously less individual benefit in lower risk people but: https://t.co/K7zuEdAots
@DrMcInnisDIT @drjohnm @AndrewFoy82 my understanding of the data is that statins are efficacious regardless of baseline risk: https://t.co/81JRLYpozA https://t.co/qihnwf9996 https://t.co/bmJfLY4M9m https://t.co/PNZYdXL3il
@Dr_ADG Interesting! @cochranecollab review reports no evidence of any increases in adverse events compared to placebo. I didn't know that. Does that suggest all those aged 55+ should be on statins? https://t.co/RLoDGQ57c0 #EveryRuleHasExceptions
@change_states @POhukainen They have benefits https://t.co/ewPDW1aQ1B https://t.co/UDEY4Xv2oX
@thenwerise @DrAseemMalhotra @MaryanneDemasi @JohnRoss49 @ProfTimNoakes @OzParadoxdotcom @FatEmperor @DrRossWalker @DrPascalMeier @drjasonfung @DrFrankLipman @markhymanmd @MJA_Editor An independent review of evidence for statins took place some years ago:
New from #OfficialNIHR https://t.co/64GU91636M Statins for the primary prevention of cardiovascular disease
“Of 1000 people treated with a statin for five years, 18 would avoid a major CVD event which compares well with other treatments used for preventing cardiovascular disease.” These odds don’t seem that good to me! https://t.co/7cAjXe6XqO
Statins for the primary prevention of cardiovascular disease. - PubMed - NCBI https://t.co/JSK2jVfGdo
Statins for the primary prevention of cardiovascular disease. - PubMed - NCBI convincing evidence for statins in the primary prevention of CVD @JaggiShalini https://t.co/or7PeHhekj
@MindsFiction @GuruAnaerobic @Mangan150 This is completely untrue. The data on statins is extremely strong. https://t.co/oKbDtBFO6y
RT @lewiskd100: @KierkegaardDTF @LaurelCoons Agree with you, but this Cochrane review does not. 18 RCTs / 57,000 patients. Cost effective f…
@KierkegaardDTF @LaurelCoons Agree with you, but this Cochrane review does not. 18 RCTs / 57,000 patients. Cost effective for primary prevention 🤷🏽♂️ https://t.co/WFrTkXKTfW
@TraderPaulFX @TomP_78 Oh mate! If you understood meta analyses (systematic reviews of multiple studies) & the independence of the Cochrane review group, this would help. I’m sure you’re an excellent trader but I would assert I may be the better Physic
RT @Hassanah2017: Good resource for health care summaries. https://t.co/lWoHj14nUb
Good resource for health care summaries.
Cochrane für alle! Auch wir helfen bei dieser Frage ("Ist das die richtige Therapie für mich?") immer gerne weiter. 🧐 https://t.co/uHQCEtqveB
RT @CochraneConsumr: Is this treatment right for me? Find out on the newly updated Cochrane Summaries https://t.co/r79jYbDfxm
RT @CochraneConsumr: Is this treatment right for me? Find out on the newly updated Cochrane Summaries https://t.co/r79jYbDfxm
Is this treatment right for me? Find out on the newly updated Cochrane Summaries https://t.co/r79jYbDfxm
RT @Students4BE: Plain Language Summaries (PLSs) help people to understand and interpret research findings and are included in all Cochrane…
RT @Students4BE: Plain Language Summaries (PLSs) help people to understand and interpret research findings and are included in all Cochrane…
RT @Students4BE: Plain Language Summaries (PLSs) help people to understand and interpret research findings and are included in all Cochrane…
RT @Students4BE: Plain Language Summaries (PLSs) help people to understand and interpret research findings and are included in all Cochrane…
Plain Language Summaries (PLSs) help people to understand and interpret research findings and are included in all Cochrane Reviews. PLSs are created using standard content, structure and language to ease understanding and translation. https://t.co/HdhBCWJs
RT @CochraneConsumr: Is this treatment right for me? Find out on the newly updated Cochrane Summaries https://t.co/r79jYbDfxm
RT @CochraneConsumr: Is this treatment right for me? Find out on the newly updated Cochrane Summaries https://t.co/r79jYbDfxm
Is this treatment right for me? Find out on the newly updated Cochrane Summaries https://t.co/r79jYbDfxm
RT @CochraneUK: Search for Plain Language Summaries of Cochrane evidence here: https://t.co/mJDu5D9MZB https://t.co/ZPSbnyuGDN
RT @CochraneUK: Search for Plain Language Summaries of health evidence here: https://t.co/mJDu5D9MZB https://t.co/2IvEh1WRB8
RT @CochraneUK: Search for Plain Language Summaries of health evidence here: https://t.co/mJDu5D9MZB https://t.co/2IvEh1WRB8
RT @CochraneUK: Search for Plain Language Summaries of health evidence here: https://t.co/mJDu5D9MZB https://t.co/2IvEh1WRB8
RT @CochraneUK: Search for Plain Language Summaries of Cochrane evidence here: https://t.co/mJDu5D9MZB https://t.co/ZPSbnyuGDN
RT @CochraneUK: Search for Plain Language Summaries of health evidence here: https://t.co/mJDu5D9MZB https://t.co/2IvEh1WRB8
RT @CochraneUK: Search for Plain Language Summaries of health evidence here: https://t.co/mJDu5D9MZB https://t.co/2IvEh1WRB8
RT @CochraneUK: Search for Plain Language Summaries of health evidence here: https://t.co/mJDu5D9MZB https://t.co/2IvEh1WRB8
RT @CochraneUK: Search for Plain Language Summaries of health evidence here: https://t.co/mJDu5D9MZB https://t.co/2IvEh1WRB8
RT @CochraneUK: Search for Plain Language Summaries of Cochrane evidence here: https://t.co/mJDu5D9MZB https://t.co/ZPSbnyuGDN
RT @CochraneUK: Search for Plain Language Summaries of health evidence here: https://t.co/mJDu5D9MZB https://t.co/2IvEh1WRB8