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Cochrane Database of Systematic Reviews

Anti‐D administration after childbirth for preventing Rhesus alloimmunisation

Overview of attention for article published in Cochrane database of systematic reviews, April 1997
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Title
Anti‐D administration after childbirth for preventing Rhesus alloimmunisation
Published in
Cochrane database of systematic reviews, April 1997
DOI 10.1002/14651858.cd000021
Pubmed ID
Authors

Caroline A Crowther, Philippa Middleton

Abstract

The development of Rh immunisation and its prophylactic use since the 1970s has meant that severe Rhesus D (RhD) alloimmunisation is now rarely seen. The objective of this systematic review was to assess the effects of giving anti-D to Rhesus negative women, with no anti-D antibodies, who had given birth to a Rhesus positive infant. We searched the Cochrane Pregnancy and Childbirth Group trials register, the Cochrane Controlled Trials Register, MEDLINE (from 1966 to January 1999) and reference lists of relevant articles. Date of last search of Cochrane Controlled Trials Register: January 1999. Randomised trials in Rhesus negative women without antibodies who were given anti-D immunoglobulin postpartum compared with no treatment or placebo. Assessments of inclusion criteria, trial quality and data extraction were done by each author independently. Initial analyses included all trials. Other analyses assessed the effect of trial quality, ABO compatibility and dose. Six eligible trials compared postpartum anti-D prophylaxis with no treatment or placebo. The trials involved over 10,000 women, but trial quality varied. Anti-D lowered the incidence of RhD alloimmunisation six months after birth (relative risk 0.04, 95% confidence interval 0.02 to 0.06), and in a subsequent pregnancy (relative risk 0.12, 95% confidence interval 0. 07 to 0.23). These benefits were seen regardless of the ABO status of the mother and baby and when anti-D was given within 72 hours of birth. Higher doses (up to 200 micro grams) were more effective than lower doses (up to 50 micro grams) in preventing RhD alloimmunisation in a subsequent pregnancy. Anti-D, given within 72 hours after childbirth, reduces the risk of RhD alloimmunisation in Rhesus negative women who have given birth to a Rhesus positive infant. However the evidence on the optimal dose is limited.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Ireland 1 <1%
Unknown 106 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 13%
Researcher 10 9%
Other 10 9%
Student > Bachelor 10 9%
Student > Master 9 8%
Other 18 17%
Unknown 37 34%
Readers by discipline Count As %
Medicine and Dentistry 28 26%
Agricultural and Biological Sciences 11 10%
Nursing and Health Professions 10 9%
Social Sciences 4 4%
Psychology 3 3%
Other 13 12%
Unknown 39 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2023.
All research outputs
#14,972,904
of 25,457,858 outputs
Outputs from Cochrane database of systematic reviews
#9,938
of 11,499 outputs
Outputs of similar age
#26,954
of 29,364 outputs
Outputs of similar age from Cochrane database of systematic reviews
#5
of 5 outputs
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