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Cochrane Database of Systematic Reviews

Huperzine A for Alzheimer's disease

Overview of attention for article published in this source, April 2008
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2 news outlets
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1 blog
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1 tweeter
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3 Wikipedia pages

Citations

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82 Dimensions

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193 Mendeley
Title
Huperzine A for Alzheimer's disease
Published by
John Wiley & Sons, Ltd, April 2008
DOI 10.1002/14651858.cd005592.pub2
Pubmed ID
Authors

Li, Jun, Wu, Hong Mei, Zhou, Rongle L, Liu, Guan Jian, Dong, Bi Rong

Abstract

Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the symptoms of AD. Cholinesterase inhibitors may block the degradation of acetylcholine, thus increasing the efficacy of the remaining cholinergic neurons. Huperzine A is a linearly competitive, reversible inhibitor of acetyl cholinesterase that is said to have both central and peripheral activity with the ability to protect cells against hydrogen peroxide, beta-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These properties might qualify Huperzine A as a promising agent for treating dementia (including AD).

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Germany 2 1%
Spain 1 <1%
Unknown 187 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 17%
Student > Master 29 15%
Student > Ph. D. Student 27 14%
Student > Bachelor 24 12%
Student > Postgraduate 13 7%
Other 34 18%
Unknown 33 17%
Readers by discipline Count As %
Medicine and Dentistry 47 24%
Psychology 24 12%
Nursing and Health Professions 18 9%
Social Sciences 11 6%
Neuroscience 10 5%
Other 42 22%
Unknown 41 21%