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Cochrane Database of Systematic Reviews

Huperzine A for Alzheimer's disease

Overview of attention for article published in this source, April 2008
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2 news outlets
1 blog
1 X user
7 Wikipedia pages
1 YouTube creator


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Readers on

243 Mendeley
Huperzine A for Alzheimer's disease
Published by
John Wiley & Sons, Ltd, April 2008
DOI 10.1002/14651858.cd005592.pub2
Pubmed ID

Li, Jun, Wu, Hong Mei, Zhou, Rongle L, Liu, Guan Jian, Dong, Bi Rong


Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the symptoms of AD. Cholinesterase inhibitors may block the degradation of acetylcholine, thus increasing the efficacy of the remaining cholinergic neurons. Huperzine A is a linearly competitive, reversible inhibitor of acetyl cholinesterase that is said to have both central and peripheral activity with the ability to protect cells against hydrogen peroxide, beta-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. These properties might qualify Huperzine A as a promising agent for treating dementia (including AD).

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 243 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Germany 2 <1%
Spain 1 <1%
Unknown 237 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 35 14%
Student > Master 33 14%
Student > Bachelor 27 11%
Student > Ph. D. Student 26 11%
Student > Doctoral Student 14 6%
Other 41 17%
Unknown 67 28%
Readers by discipline Count As %
Medicine and Dentistry 51 21%
Psychology 24 10%
Nursing and Health Professions 18 7%
Neuroscience 12 5%
Social Sciences 9 4%
Other 53 22%
Unknown 76 31%