Title |
Pegylated liposomal doxorubicin for first-line treatment of epithelial ovarian cancer
|
---|---|
Published by |
John Wiley & Sons, Ltd, October 2013
|
DOI | 10.1002/14651858.cd010482.pub2 |
Pubmed ID | |
Authors |
Lawrie, Theresa A, Rabbie, Roy, Thoma, Clemens, Morrison, Jo |
Abstract |
Epithelial ovarian cancer (EOC) is often diagnosed at an advanced stage, requiring primary cytoreductive surgery and combination chemotherapy for its first-line management. Currently, the recommended standard first-line chemotherapy is platinum-based, usually consisting of carboplatin and paclitaxel (PAC/carbo). Pegylated liposomal doxorubicin (PLD) is an improved formulation of doxorubicin that is associated with fewer and less severe side effects than are seen with non-modified doxorubicin. In combination with carboplatin, PLD has recently been shown to improve progression-free survival compared with PAC/carbo in women with relapsed, platinum-sensitive EOC. It is therefore important to know whether any survival benefit can be attributed to PLD when it is used in the first-line setting. |
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