Title |
Agomelatine versus other antidepressive agents for major depression
|
---|---|
Published in |
Cochrane database of systematic reviews, December 2013
|
DOI | 10.1002/14651858.cd008851.pub2 |
Pubmed ID | |
Authors |
Giuseppe Guaiana, Sumeet Gupta, Debbie Chiodo, Simon JC Davies, Katja Haederle, Markus Koesters |
Abstract |
Major depressive disorder (MDD), or depression, is a syndrome characterised by a number of behavioural, cognitive and emotional features. It is most commonly associated with a sad or depressed mood, a reduced capacity to feel pleasure, feelings of hopelessness, loss of energy, altered sleep patterns, weight fluctuations, difficulty in concentrating and suicidal ideation. There is a need for more effective and better tolerated antidepressants to combat this condition. Agomelatine was recently added to the list of available antidepressant drugs; it is a novel antidepressant that works on melatonergic (MT1 and MT2), 5-HT 2B and 5-HT2C receptors. Because the mechanism of action is claimed to be novel, it may provide a useful, alternative pharmacological strategy to existing antidepressant drugs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 12 | 43% |
Argentina | 2 | 7% |
France | 1 | 4% |
United Kingdom | 1 | 4% |
United States | 1 | 4% |
Unknown | 11 | 39% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 22 | 79% |
Practitioners (doctors, other healthcare professionals) | 4 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Scientists | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
Spain | 1 | <1% |
India | 1 | <1% |
United States | 1 | <1% |
Unknown | 382 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 63 | 16% |
Student > Bachelor | 43 | 11% |
Researcher | 42 | 11% |
Student > Ph. D. Student | 35 | 9% |
Student > Doctoral Student | 26 | 7% |
Other | 74 | 19% |
Unknown | 104 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 118 | 30% |
Psychology | 40 | 10% |
Nursing and Health Professions | 22 | 6% |
Social Sciences | 20 | 5% |
Agricultural and Biological Sciences | 15 | 4% |
Other | 49 | 13% |
Unknown | 123 | 32% |