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Cochrane Database of Systematic Reviews

Drugs for preventing postoperative nausea and vomiting

Overview of attention for article published in Cochrane database of systematic reviews, July 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)

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1 tweeter
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1 Wikipedia page

Citations

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15 Dimensions

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119 Mendeley
Title
Drugs for preventing postoperative nausea and vomiting
Published in
Cochrane database of systematic reviews, July 2017
DOI 10.1002/14651858.cd004125.pub3
Pubmed ID
Authors

John Carlisle, Carl A Stevenson

Abstract

Drugs can prevent postoperative nausea and vomiting, but their relative efficacies and side effects have not been compared within one systematic review. The objective of this review was to assess the prevention of postoperative nausea and vomiting by drugs and the development of any side effects. We searched The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 2, 2004), MEDLINE (January 1966 to May 2004), EMBASE (January 1985 to May 2004), CINAHL (1982 to May 2004), AMED (1985 to May 2004), SIGLE (to May 2004), ISI WOS (to May 2004), LILAC (to May 2004) and INGENTA bibliographies. We included randomized controlled trials that compared a drug with placebo or another drug, or compared doses or timing of administration, that reported postoperative nausea or vomiting as an outcome. Two authors independently assessed trial quality and extracted outcome data. We included 737 studies involving 103,237 people. Compared to placebo, eight drugs prevented postoperative nausea and vomiting: droperidol, metoclopramide, ondansetron, tropisetron, dolasetron, dexamethasone, cyclizine and granisetron. Publication bias makes evidence for differences among these drugs unreliable. The relative risks (RR) versus placebo varied between 0.60 and 0.80, depending upon the drug and outcome. Evidence for side effects was sparse: droperidol was sedative (RR 1.32) and headache was more common after ondansetron (RR 1.16). Either nausea or vomiting is reported to affect, at most, 80 out of 100 people after surgery. If all 100 of these people are given one of the listed drugs, about 28 would benefit and 72 would not. Nausea and vomiting are usually less common and, therefore, drugs are less useful. For 100 people, of whom 30 would vomit or feel sick after surgery if given placebo, 10 people would benefit from a drug and 90 would not. Between one to five patients out of every 100 people may experience a mild side effect, such as sedation or headache, when given an antiemetic drug. Collaborative research should focus on determining whether antiemetic drugs cause more severe, probably rare, side effects. Further comparison of the antiemetic effect of one drug versus another is not a research priority.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Australia 1 <1%
Unknown 117 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 15%
Student > Postgraduate 18 15%
Student > Master 11 9%
Student > Bachelor 10 8%
Other 9 8%
Other 27 23%
Unknown 26 22%
Readers by discipline Count As %
Medicine and Dentistry 68 57%
Nursing and Health Professions 10 8%
Agricultural and Biological Sciences 4 3%
Unspecified 2 2%
Computer Science 2 2%
Other 8 7%
Unknown 25 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2022.
All research outputs
#5,952,841
of 21,343,339 outputs
Outputs from Cochrane database of systematic reviews
#7,931
of 12,049 outputs
Outputs of similar age
#92,235
of 284,189 outputs
Outputs of similar age from Cochrane database of systematic reviews
#193
of 257 outputs
Altmetric has tracked 21,343,339 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 12,049 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,189 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 257 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.