↓ Skip to main content

Cochrane Database of Systematic Reviews

Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV

Overview of attention for article published in Cochrane database of systematic reviews, May 2012
Altmetric Badge

Mentioned by

news
1 news outlet

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
33 Mendeley
Title
Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV
Published in
Cochrane database of systematic reviews, May 2012
DOI 10.1002/14651858.cd007276.pub3
Pubmed ID
Authors

Omeje, Innocent, Okwundu, Charles I

Abstract

The current recommended antiretroviral treatment is a highly active antiretroviral therapy (HAART). Although HAART has been associated with improved clinical response to treatment, issues of adherence and viral resistance are major challenges limiting its success. There is a need for an effective and safe first-line regimen, to cope with the ever-increasing incidence of non-adherence and primary resistance. A more recent first-line treatment regimen consists of Tenofovir (TDF, 300 mg) + Emtricitabine (FTC, 200 mg) + Efavirenz (EFV, 600 mg). To evaluate the effects and safety of TDF + FTC + EFV as first-line treatment for patients with HIV. We searched the Cochrane Central Register of Controlled Trials, EMBASE, GATEWAY, LILACS, PubMed, AEGIS, and the WHO prospective clinical trials registry in November 2011. Randomized controlled trials evaluating the effects of TDF + FTC + EFV compared with other HAART regimens. Two reviewers independently assessed trial eligibility and risk of bias, and extracted data from the included study. Only one study involving 517 antiretroviral-naive HIV infected adults was included in this review. Participants were randomly assigned to receive either a regimen of TDF (300 mg), FTC (200mg), and EFV (600mg ) once daily; or a regimen of fixed-dose zidovudine (AZT) (300 mg) and lamivudine (3TC) (150 mg) twice daily plus EFV (600mg) once daily. Significantly more patients in the TDF-FTC group reached and maintained HIV RNA levels of less than 50 copies per milliliter compared to the AZT- 3TC group (RR 1.13; 95% CI 1.02 to 1.25). Also, more participants in the TDF-FTC group had greater increase from baseline CD4 cell counts compared to the AZT-3TC group (190 vs. 158 cells per mm(3)). More patients in the AZT-3TC group than in the TDF-FTC group had adverse events resulting in discontinuation of the study drugs (9% vs. 4%, respectively; P = 0.02). There was no statistically significant difference in all cause mortality (RR 0.50; 95% CI 0.05 to 5.46). Only one trial has shown beneficial effects and safety of TDF+ FTC + EFV as first-line treatment for patients with HIV. The effects and safety of TDF + FTC + EFV as first-line treatment for patients with HIV cannot be assessed on the basis of only one trial. Further studies evaluating the effects and safety of TDF + FTC + EFV as first-line treatment for patients with HIV are needed.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ethiopia 1 3%
France 1 3%
Unknown 31 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 33%
Researcher 6 18%
Student > Ph. D. Student 4 12%
Other 2 6%
Professor 1 3%
Other 6 18%
Unknown 3 9%
Readers by discipline Count As %
Medicine and Dentistry 18 55%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Immunology and Microbiology 2 6%
Nursing and Health Professions 2 6%
Computer Science 1 3%
Other 4 12%
Unknown 3 9%