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Cochrane Database of Systematic Reviews

Loxapine for schizophrenia

Overview of attention for article published in Cochrane database of systematic reviews, October 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
8 tweeters
weibo
1 weibo user
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
135 Mendeley
connotea
1 Connotea
Title
Loxapine for schizophrenia
Published in
Cochrane database of systematic reviews, October 2007
DOI 10.1002/14651858.cd001943.pub2
Pubmed ID
Authors

Abhijit Chakrabarti, Anne-Marie Bagnall, Pierre Chue, Mark Fenton, Vikram Palanisamy, Winson Wong, Jun Xia

Abstract

Some authors have suggested that loxapine is more effective than typical antipsychotics in reducing the negative symptoms of schizophrenia, that extrapyramidal adverse effects are not usually seen at clinically effective antipsychotic doses and that it should therefore be classed as atypical. To determine the effects of loxapine compared with placebo, typical and other atypical antipsychotic drugs for schizophrenia and related psychoses. For this 2007 update, we searched the Cochrane Schizophrenia Group's Register (January 2007). We included all randomised controlled clinical trials relevant to the care of schizophrenia that compared loxapine to other treatments. We independently inspected abstracts ordered papers, re-inspected and quality assessed these. For dichotomous data we calculated relative risks (RR) and their 95% confidence intervals (CI) on an intention-to-treat basis based on a fixed effects model. We calculated numbers needed to treat/harm (NNT/NNH) where appropriate. For continuous data, we calculated weighted mean differences (WMD) again based on a fixed effects model. We were able to include 41 studies in this review. Compared with placebo, loxapine has an antipsychotic effect (Global effect - not improved at six weeks: n=78, 2 RCTs, RR 0.30 CI 0.1 to 0.6 NNT 3 CI 3 to 5). It is as effective as typical drugs in the short term (4 -12 weeks) (Global effect: n=580, 13 RCTs, RR 0.86 CI 0.7 to 1.1; mental state: n=915, 6 RCTs, RR 0.89 CI 0.8 to 1.1). Very limited heterogeneous data suggest that, given intramuscularly (IM), loxapine may be at least as sedating as IM haloperidol and thiothixene. Loxapine is also as effective as atypicals (risperidone, quetiapine) (n=468, 6 RCTs, RR mental state not improved 1.07 CI 0.8 to 1.5). Adverse effect profile is similar to typicals but loxapine may cause more extrapyramidal adverse effects when compared with atypicals (n=340, 4 RCTs, RR 2.18 CI 1.6 to 3.1). Loxapine is an antipsychotic which is not clearly distinct from typical or atypical drugs in terms of its effects on global or mental state. Loxapines profile of adverse effects is similar to that of the older generation of antipsychotic drugs.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Chile 1 <1%
South Africa 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Unknown 130 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 25 19%
Researcher 19 14%
Student > Bachelor 17 13%
Student > Ph. D. Student 12 9%
Student > Doctoral Student 10 7%
Other 29 21%
Unknown 23 17%
Readers by discipline Count As %
Medicine and Dentistry 46 34%
Psychology 25 19%
Pharmacology, Toxicology and Pharmaceutical Science 12 9%
Nursing and Health Professions 8 6%
Agricultural and Biological Sciences 5 4%
Other 13 10%
Unknown 26 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2017.
All research outputs
#3,305,031
of 18,771,444 outputs
Outputs from Cochrane database of systematic reviews
#5,905
of 11,857 outputs
Outputs of similar age
#34,748
of 198,239 outputs
Outputs of similar age from Cochrane database of systematic reviews
#106
of 200 outputs
Altmetric has tracked 18,771,444 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,857 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.4. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,239 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 200 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.