Title |
Antidepressants for cocaine dependence
|
---|---|
Published by |
John Wiley & Sons, Ltd, April 2003
|
DOI | 10.1002/14651858.cd002950 |
Pubmed ID | |
Authors |
Silva de Lima, Maurício, Farrell, Michael, Lima Reisser, Anelise ARL, Soares, Bernardo |
Abstract |
Cocaine dependence is a common and serious condition, which has become a substantial public health problem. The past decade has witnessed a sustained search for an effective pharmacotherapeutic agent for the treatment of cocaine dependence. While administration of cocaine acutely increases intercellular dopamine, serotonin, and norepinephrine levels by blocking their presynaptic reuptake, chronic cocaine abuse leads to down-regulation of monoamine systems. Post-cocaine use depression and cocaine craving may be linked to this down-regulation. Antidepressant pharmacotherapy, by augmenting monoamine levels, may alleviate cocaine abstinence symptomatology, as well as relieving dysphoria and associated craving by general antidepressant action. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 17% |
Researcher | 4 | 13% |
Professor > Associate Professor | 3 | 10% |
Student > Master | 3 | 10% |
Student > Postgraduate | 2 | 7% |
Other | 6 | 20% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 27% |
Neuroscience | 5 | 17% |
Psychology | 3 | 10% |
Decision Sciences | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 7% |
Unknown | 10 | 33% |