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Cochrane Database of Systematic Reviews

Antidepressants for cocaine dependence

Overview of attention for article published in this source, April 2003
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24 Mendeley
Title
Antidepressants for cocaine dependence
Published by
John Wiley & Sons, Ltd, April 2003
DOI 10.1002/14651858.cd002950
Pubmed ID
Authors

Silva de Lima, Maurício, Farrell, Michael, Lima Reisser, Anelise ARL, Soares, Bernardo

Abstract

Cocaine dependence is a common and serious condition, which has become a substantial public health problem. The past decade has witnessed a sustained search for an effective pharmacotherapeutic agent for the treatment of cocaine dependence. While administration of cocaine acutely increases intercellular dopamine, serotonin, and norepinephrine levels by blocking their presynaptic reuptake, chronic cocaine abuse leads to down-regulation of monoamine systems. Post-cocaine use depression and cocaine craving may be linked to this down-regulation. Antidepressant pharmacotherapy, by augmenting monoamine levels, may alleviate cocaine abstinence symptomatology, as well as relieving dysphoria and associated craving by general antidepressant action.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 17%
Researcher 4 17%
Professor > Associate Professor 3 13%
Student > Master 3 13%
Student > Postgraduate 2 8%
Other 6 25%
Unknown 2 8%
Readers by discipline Count As %
Medicine and Dentistry 7 29%
Neuroscience 5 21%
Psychology 3 13%
Decision Sciences 1 4%
Social Sciences 1 4%
Other 2 8%
Unknown 5 21%