Cochrane zdravlje,
Antagonisti receptora za leukotriene kao terapija održavanja i terapija po potrebi za povremeno virusno „sviranje pluća u djece…
Antagonisti receptora za leukotriene kao terapija održavanja i terapija po potrebi za povremeno virusno „sviranje pluća u djece…
(3/3) Likely that children with apparent EVW are not a homogeneous group and may respond to LTRA differently http://ow.ly/TChJw
(2/3) When LTRA used, we suggest a therapeutic trial is undertaken, during which efficacy is carefully monitored http://ow.ly/TCh…
Bottom line (1/3) Until further data are available, LTRA should be used with caution in individual children... http://ow.ly/TChJw…
...and little evidence of significant clinical benefit for other secondary outcomes... http://onlinelibrary.wiley.com/doi/10.1002…
Intermittent LTRA: no sig diff in children with one or more episodes requiring rescue OCS http://ow.ly/TChrS
Maintenance LTRA: one study showed no sig diff in number of episodes requiring rescue OCS http://ow.ly/TCgNk
Review included 5 studies on 3741 children. All oral montelukast vs placebo and good methodological quality http://ow.ly/TCgAH
New #Cochrane Review: LTRA as maintenance and intermittent therapy for episodic viral wheeze in children http://ow.ly/TCgic