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Cochrane Database of Systematic Reviews

Pharmacological interventions for unilateral spatial neglect after stroke

Overview of attention for article published in Cochrane database of systematic reviews, November 2015
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Title
Pharmacological interventions for unilateral spatial neglect after stroke
Published in
Cochrane database of systematic reviews, November 2015
DOI 10.1002/14651858.cd010882.pub2
Pubmed ID
Authors

Gustavo José Luvizutto, Rodrigo Bazan, Gabriel Pereira Braga, Luiz Antônio de Lima Resende, Silméia Garcia Z Bazan, Regina El Dib

Abstract

Unilateral spatial neglect (USN) is characterized by the inability to report or respond to people or objects presented on the side contralateral to the lesioned side of the brain and has been associated with poor functional outcomes and long stays in hospitals and rehabilitation centers. Pharmacological interventions (medical interventions only, use of drugs to improve the health condition), such as dopamine and noradrenergic agonists or pro-cholinergic treatment, have been used in people affected by USN after stroke, and effects of these treatments could provide new insights for health professionals and policy makers. To evaluate the effectiveness and safety of pharmacological interventions for USN after stroke. We searched the Cochrane Stroke Group Trials Register (April 2015), the Cochrane Central Register of Controlled Trials (April 2015), MEDLINE (1946 to April 2015), the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (1982 to April 2015), EMBASE (1980 to April 2015), PsycINFO (1806 to April 2015) and Latin American Caribbean Health Sciences Literature (LILACS) (1982 to April 2015). We also searched trials and research registers, screened reference lists, and contacted study authors and pharmaceutical companies (April 2015). We included randomized controlled trials (RCTs) and quasi-randomized controlled trials (quasi-RCTs) of pharmacological interventions for USN after stroke. Two review authors independently assessed risk of bias in the included studies and extracted data. We included in the review two studies with a total of 30 randomly assigned participants. We rated the quality of the evidence as very low as the result of study limitations, small numbers of events, and small sample sizes, with imprecision in the confidence interval (CI). We were not able to perform meta-analysis because of heterogeneity related to the different interventions evaluated between included studies. Very low-quality evidence from one trial (20 participants) comparing effects of rivastigmine plus rehabilitation versus rehabilitation on overall USN at discharge showed the following: Barrage (mean difference (MD) 0.30, 95% confidence interval (CI) -0.18 to 0.78); Letter Cancellation (MD 10.60, 95% CI 2.07 to 19.13); Sentence Reading (MD 0.20, 95% CI -0.69 to 1.09), and the Wundt-Jastrow Area Illusion Test (MD -4.40, 95% CI -8.28 to -0.52); no statistical significance was observed for the same outcomes at 30 days' follow-up. In another trial (10 participants), study authors showed statistically significant reduction in omissions in the three cancellation tasks under transdermal nicotine treatment (mean number of omissions 2.93 ± 0.5) compared with both baseline (4.95 ± 0.8) and placebo (5.14 ± 0.9) (main effect of treatment condition: F (2.23) = 11.06; P value < 0.0001). One major adverse event occurred in the transdermal nicotine treatment group, and treatment was discontinued in the affected participant. None of the included trials reported data on several of the prespecified outcomes (falls, balance, depression or anxiety, poststroke fatigue, and quality of life). The quality of the evidence from available RCTs was very low. The effectiveness and safety of pharmacological interventions for USN after stroke are therefore uncertain. Additional large RCTs are needed to evaluate these treatments.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 341 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
Portugal 1 <1%
Unknown 338 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 51 15%
Student > Bachelor 36 11%
Researcher 33 10%
Student > Ph. D. Student 27 8%
Student > Doctoral Student 19 6%
Other 54 16%
Unknown 121 35%
Readers by discipline Count As %
Medicine and Dentistry 69 20%
Nursing and Health Professions 51 15%
Psychology 23 7%
Neuroscience 17 5%
Social Sciences 12 4%
Other 40 12%
Unknown 129 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2019.
All research outputs
#16,580,489
of 26,150,873 outputs
Outputs from Cochrane database of systematic reviews
#11,258
of 13,188 outputs
Outputs of similar age
#160,349
of 298,684 outputs
Outputs of similar age from Cochrane database of systematic reviews
#263
of 301 outputs
Altmetric has tracked 26,150,873 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,188 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.7. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,684 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 301 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.