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Cochrane Database of Systematic Reviews

Hyperventilation therapy for acute traumatic brain injury

Overview of attention for article published in Cochrane database of systematic reviews, October 1997
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Hyperventilation therapy for acute traumatic brain injury
Published in
Cochrane database of systematic reviews, October 1997
DOI 10.1002/14651858.cd000566
Pubmed ID

Ian Roberts, Gillian Schierhout


Because hyperventilation is often associated with a rapid fall in intracranial pressure, it has been assumed to be effective in the treatment of severe head injury. Hyperventilation reduces raised intracranial pressure by causing cerebral vasoconstriction and a reduction in cerebral blood flow. Whether reduced cerebral blood flow improves neurological outcome however, is unclear. To quantify the effect of hyperventilation on death and neurological disability following head injury. The search strategy drew on that of the Injuries Group as a whole. The reference lists of all relevant articles identified were checked and the first author of reports was contacted to ask for assistance in identifying any further trials. Most recent search was done in September 1999. All randomised trials of hyperventilation, in which study participants had a clinically defined acute traumatic head injury of any severity. There were no language restrictions. We collected data on the participants, the timing and duration of the intervention, duration of follow up, neurological disability and death. Relative risks (RR) and 95% confidence intervals were calculated for each trial on an intention to treat basis. Timing, degree and duration of hyperventilation were identified a-priori as potential sources of heterogeneity between trials. One trial of 113 participants was identified. Hyperventilation alone, as well as in conjunction with the buffer THAM showed a beneficial effect on mortality at one year after injury, although the effect measure was imprecise (RR=0.73; 95% CI 0.36;1.49 and RR=0.89; 95% CI 0.47;1.72 respectively). This improvement in outcome was not supported by an improvement in neurological recovery. For hyperventilation alone, the RR for death or severe disability was 1. 14 (95% CI 0.82;1.58). The RR for death or severe disability in the hyperventilation plus THAM group, was 0.87 (95% CI 0.58;1.28). The data available are inadequate to assess any potential benefit or harm that might result from hyperventilation in severe head injury. Randomised controlled trials to assess the effectiveness of hyperventilation therapy following severe head injury are needed.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 <1%
Unknown 108 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 13%
Researcher 13 12%
Student > Master 10 9%
Student > Ph. D. Student 9 8%
Other 7 6%
Other 27 25%
Unknown 29 27%
Readers by discipline Count As %
Medicine and Dentistry 46 42%
Nursing and Health Professions 7 6%
Psychology 5 5%
Engineering 4 4%
Biochemistry, Genetics and Molecular Biology 3 3%
Other 12 11%
Unknown 32 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2020.
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of 22,836,570 outputs
Outputs from Cochrane database of systematic reviews
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Outputs of similar age
of 31,253 outputs
Outputs of similar age from Cochrane database of systematic reviews
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