Piracetam for reducing the incidence of painful sickle cell disease crises.
Cochrane database of systematic reviews, April 2007
Al Hajeri AA, Fedorowicz Z, Omran A, Tadmouri GO, Al Hajeri, Amani, Fedorowicz, Zbys, Omran, Ahmed, Tadmouri, Ghazi O
Sickle cell disease is one of the most common genetic disorders. Sickle cell crises in which irregular and dehydrated cells contribute to blocking of blood vessels are characterised by episodes of pain. Treatment is mainly supportive and symptomatic. In vitro studies with piracetam indicate that it has the potential for inhibition and a reversal of the process of sickling of erythrocytes.
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