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Cochrane Database of Systematic Reviews

Topical capsaicin (high concentration) for chronic neuropathic pain in adults

Overview of attention for article published in this source, February 2013
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Mentioned by

1 blog
28 tweeters
3 Facebook pages


238 Dimensions

Readers on

184 Mendeley
Topical capsaicin (high concentration) for chronic neuropathic pain in adults
Published by
John Wiley & Sons, Ltd, February 2013
DOI 10.1002/14651858.cd007393.pub3
Pubmed ID

Derry, Sheena, Rice, Andrew S C, Cole, Peter, Tan, Toni, Moore, R Andrew


Topical creams with capsaicin are used to treat peripheral neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. High-concentration (8%) capsaicin patches were developed to increase the amount of capsaicin delivered; rapid delivery was thought to improve tolerability because cutaneous nociceptors are 'defunctionalised' quickly. The single application avoids noncompliance. Only the 8% patch formulation of capsaicin is available, with a capsaicin concentration about 100 times greater than conventional creams.High-concentration topical capsaicin is given as a single patch application to the affected part. It must be applied under highly controlled conditions, normally under local anaesthetic, due to the initial intense burning sensation it causes. The benefits are expected to last for about 12 weeks, when another application might be made.

Twitter Demographics

The data shown below were collected from the profiles of 28 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Germany 2 1%
South Africa 1 <1%
Brazil 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 175 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 17%
Student > Master 30 16%
Student > Bachelor 24 13%
Student > Ph. D. Student 22 12%
Other 17 9%
Other 43 23%
Unknown 17 9%
Readers by discipline Count As %
Medicine and Dentistry 92 50%
Nursing and Health Professions 13 7%
Agricultural and Biological Sciences 12 7%
Pharmacology, Toxicology and Pharmaceutical Science 9 5%
Psychology 9 5%
Other 26 14%
Unknown 23 13%