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Cochrane Database of Systematic Reviews

Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour

Overview of attention for article published in Cochrane database of systematic reviews, July 2010
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Title
Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour
Published in
Cochrane database of systematic reviews, July 2010
DOI 10.1002/14651858.cd000940.pub2
Pubmed ID
Authors

Han, Shanshan, Crowther, Caroline A, Moore, Vivienne

Abstract

Magnesium maintenance therapy is one of the types of tocolytic therapy used after an episode of threatened preterm labour (usually treated with an initial dose of tocolytic therapy) in an attempt to prevent the onset of further preterm contractions. To assess whether magnesium maintenance therapy is effective in preventing preterm birth after the initial threatened preterm labour is arrested. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (May 2010). Randomised controlled trials of magnesium therapy given to women after threatened preterm labour. The review authors independently assessed the studies for inclusion, assessed risk of bias and carried out data extraction. We checked data entry. We included four trials, which recruited 422 women. Three trials had high risk of bias and none included any long-term follow up of infants. No differences in the incidence of preterm birth or perinatal mortality were seen when magnesium maintenance therapy was compared with placebo or no treatment; or alternative therapies (ritodrine or terbutaline). The risk ratio (RR) for preterm birth (less than 37 weeks) for magnesium compared with placebo or no treatment was 1.05, 95% confidence interval (CI) 0.80 to 1.40 (two trials, 99 women); and 0.99, 95% CI 0.57 to 1.72 (2 trials, 100 women) for magnesium compared with alternative therapies. The RR for perinatal mortality for magnesium compared with placebo or no treatment was 5.00, 95% CI 0.25 to 99.16 (one trial, 50 infants) and also compared with alternative treatments, was 5.00, 95% CI 0.25 to 99.16 (one trial, 50 infants). Women taking magnesium preparations were less likely to report palpitations or tachycardia than women receiving alternative therapies (RR 0.26, 95% CI 0.13 to 0.52, three trials, 237 women) but were much more likely to experience diarrhoea (RR 7.66, 95% CI 2.18 to 26.98, three trials, 237 women). There is not enough evidence to show any difference between magnesium maintenance therapy compared with either placebo or no treatment, or alternative therapies (ritodrine or terbutaline) in preventing preterm birth after an episode of threatened preterm labour.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 2 5%
Brazil 1 3%
Unknown 36 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 15%
Student > Doctoral Student 6 15%
Student > Bachelor 5 13%
Researcher 3 8%
Student > Master 3 8%
Other 6 15%
Unknown 10 26%
Readers by discipline Count As %
Medicine and Dentistry 18 46%
Nursing and Health Professions 4 10%
Agricultural and Biological Sciences 3 8%
Biochemistry, Genetics and Molecular Biology 2 5%
Social Sciences 2 5%
Other 2 5%
Unknown 8 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2020.
All research outputs
#21,260,385
of 26,107,266 outputs
Outputs from Cochrane database of systematic reviews
#12,284
of 13,187 outputs
Outputs of similar age
#97,140
of 107,449 outputs
Outputs of similar age from Cochrane database of systematic reviews
#64
of 70 outputs
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