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Cochrane Database of Systematic Reviews

Amodiaquine for treating malaria

Overview of attention for article published in Cochrane database of systematic reviews, April 2003
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

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6 Wikipedia pages


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Readers on

138 Mendeley
Amodiaquine for treating malaria
Published in
Cochrane database of systematic reviews, April 2003
DOI 10.1002/14651858.cd000016
Pubmed ID

Piero L Olliaro, Paola Mussano


Amodiaquine has been widely used to treat malaria. Fatal adverse reactions have been reported in adults taking it for prophylaxis. This has led some authorities to suggest it is withdrawn as a first line treatment for malaria. To compare amodiaquine with chloroquine or sulfadoxine-pyrimethamine for treating uncomplicated Plasmodium falciparum malaria. We searched the Cochrane Infectious Diseases Group specialized trials register (February 2003), The Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 1, 2003), MEDLINE (1966 to February 2003), EMBASE (1980 to December 2002), LILACS (February 2003). We contacted researchers in the field and pharmaceutical companies. Randomised and quasi-randomised trials. Two reviewers independently extracted data and assessed trial quality. 56 studies included, mostly from Africa. Treatment allocation was adequately concealed in three trials, and unclear or inadequate in the remainder. Amodiaquine was more effective than chloroquine for parasite clearance (day 7, Peto odds ratio 4.42 (95% confidence interval 3.65 to 5.35); day 14, Peto odds ratio 6.44 (95% confidence interval (CI) 5.09 to 8.15). Comparisons with sulfadoxine/pyrimethamine were more mixed, with sulfadoxine/pyrimethamine more effective on day 28 (Peto odds ratio 0.41; 95% CI 0.28 to 0.61). No significant difference for adverse events was observed between amodiaquine and chloroquine and sulfadoxine/pyrimethamine. Reported adverse effects were minor or moderate. No life threatening events were detected. There is evidence to support the continued use of amodiaquine to treat uncomplicated malaria, although local drug resistance patterns need to be considered. Monitoring for adverse events should continue.

Mendeley readers

The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
France 1 <1%
Tanzania, United Republic of 1 <1%
Kenya 1 <1%
Belgium 1 <1%
Unknown 132 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 19%
Student > Ph. D. Student 24 17%
Student > Master 17 12%
Student > Bachelor 11 8%
Student > Postgraduate 9 7%
Other 23 17%
Unknown 28 20%
Readers by discipline Count As %
Medicine and Dentistry 43 31%
Agricultural and Biological Sciences 16 12%
Biochemistry, Genetics and Molecular Biology 13 9%
Nursing and Health Professions 7 5%
Chemistry 7 5%
Other 21 15%
Unknown 31 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2022.
All research outputs
of 21,763,118 outputs
Outputs from Cochrane database of systematic reviews
of 12,101 outputs
Outputs of similar age
of 425,668 outputs
Outputs of similar age from Cochrane database of systematic reviews
of 151 outputs
Altmetric has tracked 21,763,118 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,101 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,668 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 151 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.