↓ Skip to main content

Cochrane Database of Systematic Reviews

High‐dose opioids for chronic non‐cancer pain: an overview of Cochrane Reviews

Overview of attention for article published in Cochrane database of systematic reviews, March 2023
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)

Mentioned by

twitter
7 X users

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
41 Mendeley
Title
High‐dose opioids for chronic non‐cancer pain: an overview of Cochrane Reviews
Published in
Cochrane database of systematic reviews, March 2023
DOI 10.1002/14651858.cd012299.pub3
Pubmed ID
Authors

Charl Els, Tanya D Jackson, Reidar Hagtvedt, Diane Kunyk, Barend Sonnenberg, Vernon G Lappi, Sebastian Straube

Abstract

This overview was originally published in 2017, and is being updated in 2022.  Chronic pain is typically described as pain on most days for at least three months. Chronic non-cancer pain (CNCP) is any chronic pain that is not due to a malignancy. Chronic non-cancer pain in adults is a common and complex clinical issue, for which opioids are prescribed by some physicians for pain management. There are concerns that the use of high doses of opioids for CNCP lacks evidence of effectiveness, and may increase the risk of adverse events. To describe the evidence from Cochrane Reviews and overviews regarding the efficacy and safety of high-dose opioids (defined as 200 mg morphine equivalent or more per day) for CNCP. We identified Cochrane Reviews and overviews by searching the Cochrane Database of Systematic Reviews in The Cochrane Library. The date of the last search was 21 July 2022. Two overview authors independently assessed the search results. We planned to analyse data on any opioid agent used at a high dose for two weeks or more for the treatment of CNCP in adults. We did not identify any reviews or overviews that met the inclusion criteria. The excluded reviews largely reflected low doses or titrated doses, where all doses were analysed as a single group; we were unable to extract any data for high-dose use only. There is a critical lack of high-quality evidence, in the form of Cochrane Reviews, about how well high-dose opioids work for the management of CNCP in adults, and regarding the presence and severity of adverse events.  No evidence-based argument can be made on the use of high-dose opioids, i.e. 200 mg morphine equivalent or more daily, in clinical practice. Considering that high-dose opioids have been, and are still being used in clinical practice to treat CNCP, knowing about the efficacy and safety of these higher doses is imperative.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 20%
Student > Doctoral Student 3 7%
Student > Master 3 7%
Student > Ph. D. Student 3 7%
Student > Postgraduate 2 5%
Other 4 10%
Unknown 18 44%
Readers by discipline Count As %
Medicine and Dentistry 15 37%
Nursing and Health Professions 2 5%
Economics, Econometrics and Finance 2 5%
Agricultural and Biological Sciences 1 2%
Unspecified 1 2%
Other 2 5%
Unknown 18 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2023.
All research outputs
#8,270,860
of 25,394,764 outputs
Outputs from Cochrane database of systematic reviews
#8,916
of 11,487 outputs
Outputs of similar age
#145,021
of 421,625 outputs
Outputs of similar age from Cochrane database of systematic reviews
#97
of 106 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 11,487 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.9. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,625 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.