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| Title |
Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis
|
|---|---|
| Published in |
Cochrane database of systematic reviews, July 2013
|
| DOI | 10.1002/14651858.cd007168.pub3 |
| Pubmed ID | |
| Authors |
Julian Tam, Edward F Nash, Felix Ratjen, Elizabeth Tullis, Anne Stephenson |
| Abstract |
Cystic fibrosis is an inherited condition resulting in thickened, sticky respiratory secretions. Respiratory failure, due to recurrent pulmonary infection and inflammation, is the most common cause of mortality. Muco-active therapies (e.g. dornase alfa and nebulized hypertonic saline) may decrease sputum viscosity, increase airway clearance of sputum, reduce infection and inflammation and improve lung function. Thiol derivatives, either oral or nebulized, have shown benefit in other respiratory diseases. Their mode of action is likely to differ according to the route of administration. There are several thiol derivatives, and it is unclear which of these may be beneficial in cystic fibrosis. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 146 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 13% |
| Student > Ph. D. Student | 17 | 12% |
| Researcher | 15 | 10% |
| Student > Bachelor | 13 | 9% |
| Other | 9 | 6% |
| Other | 28 | 19% |
| Unknown | 46 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 55 | 37% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 7% |
| Nursing and Health Professions | 9 | 6% |
| Agricultural and Biological Sciences | 5 | 3% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Other | 14 | 10% |
| Unknown | 50 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2023.
All research outputs
#5,552,734
of 26,374,136 outputs
Outputs from Cochrane database of systematic reviews
#7,587
of 13,211 outputs
Outputs of similar age
#43,103
of 208,732 outputs
Outputs of similar age from Cochrane database of systematic reviews
#187
of 335 outputs
Altmetric has tracked 26,374,136 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,211 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.7. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,732 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 335 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.