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Cochrane Database of Systematic Reviews

Bisphosphonates for the relief of pain secondary to bone metastases

Overview of attention for article published in Cochrane database of systematic reviews, April 2002
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Citations

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252 Dimensions

Readers on

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182 Mendeley
Title
Bisphosphonates for the relief of pain secondary to bone metastases
Published in
Cochrane database of systematic reviews, April 2002
DOI 10.1002/14651858.cd002068
Pubmed ID
Authors

Rebecca KS Wong, Philip J Wiffen

Abstract

Bisphosphonates form part of standard therapy for hypercalcemia and the prevention of skeletal events in some cancers. However, the role of bisphosphonates in pain relief for bony metastases remains uncertain. To determine the effectiveness of bisphosphonates for the relief of pain from bone metastases. MEDLINE (1966-1999), EMBASE (1980-1999), CancerLit (1966-1999), the Cochrane library (Issue 1, 2000) and the Oxford Pain Database were searched using the strategy devised by the Cochrane Pain, Palliative and Supportive Care Group with additional terms 'diphosphonate', 'bisphosphonate', 'multiple myeloma' and 'bone neoplasms'. (Last search: January 2000). Randomized trials of bisphosphonates compared with open, blinded, or different doses/types of bisphosphonates in cancer patients were included where pain and/or analgesic consumption were outcome measures. Studies where pain was reported only by observers were excluded. Article eligibility, quality assessment and data extraction were undertaken by both reviewers. The proportions of patients with pain relief at 4, 8 and 12 weeks were assessed. The proportion of patients with analgesic reduction, the mean pain score, mean analgesic consumption, adverse drug reactions, and quality of life data were compared as secondary outcomes. Thirty randomized controlled studies (21 blinded, four open and five active control) with a total of 3682 subjects were included. For each outcome, there were few studies with available data. For the proportion of patients with pain relief (eight studies) pooled data showed benefits for the treatment group, with an NNT at 4 weeks of 11[95% CI 6-36] and at 12 weeks of 7 [95% CI 5-12]. In terms of adverse drug reactions, the NNH was 16 [95% CI 12-27] for discontinuation of therapy. Nausea and vomiting were reported in 24 studies with a non-significant trend for greater risk in the treatment group. One study showed a small improvement in quality of life for the treatment group at 4 weeks. The small number of studies in each subgroup with relevant data limited our ability to explore the most effective bisphosphonates and their relative effectiveness for different primary neoplasms. There is evidence to support the effectiveness of bisphosphonates in providing some pain relief for bone metastases. There is insufficient evidence to recommend bisphosphonates for immediate effect; as first line therapy; to define the most effective bisphosphonates or their relative effectiveness for different primary neoplasms. Bisphosphonates should be considered where analgesics and/or radiotherapy are inadequate for the management of painful bone metastases.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Switzerland 1 <1%
Malaysia 1 <1%
Portugal 1 <1%
Australia 1 <1%
Hong Kong 1 <1%
Canada 1 <1%
United States 1 <1%
Unknown 172 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 25 14%
Other 22 12%
Researcher 22 12%
Student > Bachelor 18 10%
Student > Ph. D. Student 14 8%
Other 39 21%
Unknown 42 23%
Readers by discipline Count As %
Medicine and Dentistry 81 45%
Nursing and Health Professions 14 8%
Agricultural and Biological Sciences 10 5%
Biochemistry, Genetics and Molecular Biology 6 3%
Pharmacology, Toxicology and Pharmaceutical Science 6 3%
Other 21 12%
Unknown 44 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2018.
All research outputs
#5,870,000
of 22,747,498 outputs
Outputs from Cochrane database of systematic reviews
#7,659
of 12,315 outputs
Outputs of similar age
#37,218
of 121,098 outputs
Outputs of similar age from Cochrane database of systematic reviews
#13
of 34 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 12,315 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,098 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.