Title |
Gemcitabine for unresectable, locally advanced or metastatic bladder cancer
|
---|---|
Published in |
Cochrane database of systematic reviews, April 2011
|
DOI | 10.1002/14651858.cd008976.pub2 |
Pubmed ID | |
Authors |
Mike Shelley, Anne Cleves, Timothy J Wilt, Malcolm Mason |
Abstract |
The prognosis for unresectable, locally advanced or metastatic transitional cell carcinoma of the bladder is poor with most patients succumbing to their disease within 2 to 3 years. Clinical management at this stage of the disease is palliative with systemic chemotherapy the main treatment of choice. A number of cytotoxic agents have shown activity in metastatic disease including cisplatin, methotrexate, doxorubicin and vinblastine. However, response rates still need improving and toxicities may sometimes be severe, and so the search for newer agents with improved benefit-to-risk ratios is constantly being pursued. One such agent that shows promise is gemcitabine. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Switzerland | 1 | <1% |
Unknown | 117 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 17 | 14% |
Student > Ph. D. Student | 13 | 11% |
Student > Bachelor | 13 | 11% |
Researcher | 8 | 7% |
Other | 8 | 7% |
Other | 27 | 23% |
Unknown | 34 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 55 | 46% |
Nursing and Health Professions | 7 | 6% |
Biochemistry, Genetics and Molecular Biology | 5 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Agricultural and Biological Sciences | 4 | 3% |
Other | 9 | 8% |
Unknown | 36 | 30% |