| Title |
Methotrexate for induction of remission in refractory Crohn's disease
|
|---|---|
| Published in |
Cochrane database of systematic reviews, August 2014
|
| DOI | 10.1002/14651858.cd003459.pub4 |
| Pubmed ID | |
| Authors |
John WD McDonald, Yongjun Wang, David J Tsoulis, John K MacDonald, Brian G Feagan |
| Abstract |
Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrexate as a treatment for rheumatoid arthritis led to its evaluation in patients with refractory Crohn's disease. Methotrexate has been studied for induction of remission of refractory Crohn's disease and has become the principal alternative to azathioprine or 6-mercaptopurine therapy. This systematic review is an update of previously published Cochrane reviews. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 21% |
| United States | 5 | 21% |
| Canada | 2 | 8% |
| Brazil | 1 | 4% |
| Turkey | 1 | 4% |
| United Kingdom | 1 | 4% |
| Norway | 1 | 4% |
| Unknown | 8 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 79% |
| Practitioners (doctors, other healthcare professionals) | 4 | 17% |
| Scientists | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 277 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Colombia | 1 | <1% |
| Brazil | 1 | <1% |
| Italy | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 270 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 14% |
| Student > Master | 35 | 13% |
| Researcher | 34 | 12% |
| Student > Bachelor | 26 | 9% |
| Other | 22 | 8% |
| Other | 50 | 18% |
| Unknown | 71 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 116 | 42% |
| Nursing and Health Professions | 14 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 5% |
| Agricultural and Biological Sciences | 9 | 3% |
| Psychology | 7 | 3% |
| Other | 35 | 13% |
| Unknown | 82 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2014.
All research outputs
#2,197,703
of 25,806,763 outputs
Outputs from Cochrane database of systematic reviews
#4,548
of 13,140 outputs
Outputs of similar age
#21,381
of 242,435 outputs
Outputs of similar age from Cochrane database of systematic reviews
#84
of 239 outputs
Altmetric has tracked 25,806,763 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,140 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.9. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,435 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 239 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.