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Cochrane Database of Systematic Reviews

Aminoadamantanes versus other antiviral drugs for chronic hepatitis C

Overview of attention for article published in Cochrane database of systematic reviews, June 2014
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Title
Aminoadamantanes versus other antiviral drugs for chronic hepatitis C
Published in
Cochrane database of systematic reviews, June 2014
DOI 10.1002/14651858.cd011132.pub2
Pubmed ID
Authors

Mieke H Lamers, Mark Broekman, Joostrenth, Christian Gluud

Abstract

Hepatitis C virus infection affects around 3% of the world population or approximately 160 million people. A variable proportion (5% to 40%) of the infected people develop clinical symptoms. Hence, hepatitis C virus is a leading cause of liver-related morbidity and mortality with hepatic fibrosis, end-stage liver cirrhosis, and hepatocellular carcinoma as the dominant clinical sequelae. Combination therapy with pegylated (peg) interferon-alpha and ribavirin achieves sustained virological response (that is, undetectable hepatitis C virus RNA in serum by sensitivity testing six months after the end of treatment) in approximately 40% to 80% of treated patients, depending on viral genotype. Recently, a new class of drugs have emerged for hepatitis C infection, the direct acting antivirals, which in combination with standard therapy or alone can lead to sustained virological response in 80% or more of treated patients. Aminoadamantanes, mostly amantadine, are antiviral drugs used for the treatment of patients with chronic hepatitis C. We have previously systematically reviewed amantadine versus placebo or no intervention and found no significant effects of the amantadine on all-cause mortality or liver-related morbidity and on adverse events in patients with hepatitis C. Overall, we did not observe a significant effect of amantadine on sustained virological response. In this review, we systematically review aminoadamantanes versus other antiviral drugs.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 136 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 19%
Student > Ph. D. Student 17 12%
Student > Bachelor 12 9%
Student > Postgraduate 11 8%
Other 8 6%
Other 24 18%
Unknown 39 28%
Readers by discipline Count As %
Medicine and Dentistry 46 34%
Nursing and Health Professions 12 9%
Psychology 7 5%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Biochemistry, Genetics and Molecular Biology 3 2%
Other 16 12%
Unknown 49 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2014.
All research outputs
#20,723,696
of 25,457,858 outputs
Outputs from Cochrane database of systematic reviews
#10,914
of 11,499 outputs
Outputs of similar age
#178,195
of 242,813 outputs
Outputs of similar age from Cochrane database of systematic reviews
#217
of 228 outputs
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