| Title |
QTc interval screening for cardiac risk in methadone treatment of opioid dependence
|
|---|---|
| Published in |
Cochrane database of systematic reviews, June 2013
|
| DOI | 10.1002/14651858.cd008939.pub2 |
| Pubmed ID | |
| Authors |
Pier Paolo Pani, Emanuela Trogu, Icro Maremmani, Matteo Pacini |
| Abstract |
Methadone represents today the gold standard of efficacy for the pharmacological treatment of opioid dependence. Methadone, like many other medications, has been implicated in the prolongation of the rate-corrected QT (QTc) interval of the electrocardiogram (ECG), which is considered a marker for arrhythmias such as torsade de pointes (TdP). Indications on the association between methadone, even at therapeutic dosages, and TdP or sudden cardiac death have been reported. On these bases, consensus and recommendations involving QTc screening of patients receiving methadone treatment have been developed to identify patients with QTc above the thresholds considered at risk for cardiac arrhythmias, and they provide these individuals with alternative treatment (reduction of methadone dosage; provision of alternative opioid agonist treatment; treatment of associated risk factors). |
Twitter Demographics
The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| Ireland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| Unknown | 166 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 15% |
| Student > Master | 24 | 14% |
| Student > Ph. D. Student | 16 | 10% |
| Other | 12 | 7% |
| Researcher | 9 | 5% |
| Other | 30 | 18% |
| Unknown | 51 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 63 | 38% |
| Nursing and Health Professions | 15 | 9% |
| Psychology | 12 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Agricultural and Biological Sciences | 5 | 3% |
| Other | 14 | 8% |
| Unknown | 52 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2019.
All research outputs
#14,584,289
of 24,469,913 outputs
Outputs from Cochrane database of systematic reviews
#10,699
of 12,925 outputs
Outputs of similar age
#108,611
of 201,041 outputs
Outputs of similar age from Cochrane database of systematic reviews
#223
of 284 outputs
Altmetric has tracked 24,469,913 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,925 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.7. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,041 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 284 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.