@EM_Dr_Jacklin @nathan_warner It's worth looking at post MI Mg2+ Meta-analysis of small trials suggested benefit LIMIT-2 (n=2316) showed small benefit at ~3 hrs post onset but ISIS-4 (n>58000) showed no benefit - at ~8 hr post onset => beware publica

@giovanni_ef @gero5 This is a general problem with random effects models. See for e.g. https://t.co/My1nmguLAR or Handbook of MA by Schmid; Chapter 6

@djc795 @jedicath @drjohnm And systematic review of trials of Mg in STEMI suggests mortality benefit https://t.co/QHp53yxcmF

@NNShahMD @thecurbsiders @TWDFNR @sandeepdasmd There's mixed RCT data in an ACS population (https://t.co/mgxRNTCVp5) and I believe that may be the basis for some of the general teachings about Mg and inpatient cardiology