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Cochrane Database of Systematic Reviews

Puerarin for ischaemic stroke

Overview of attention for article published in Cochrane database of systematic reviews, February 2016
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Puerarin for ischaemic stroke
Published in
Cochrane database of systematic reviews, February 2016
DOI 10.1002/14651858.cd004955.pub3
Pubmed ID

Bian Liu, Yan Tan, Deren Wang, Ming Liu


Puerarin, a form of herbal medicine, is widely used in the treatment of ischaemic stroke in China. To assess the effects of puerarin in people with ischaemic stroke. We searched the Cochrane Stroke Group Trials Register and the Chinese Stroke Trials Register (last searched August 2015). In addition, we searched the Cochrane Central Register of Controlled Trials (CENTRAL) (2015, Issue 7), MEDLINE (1948 to August 2015), EMBASE (1980 to August 2015), AMED (the Allied and Complementary Medicine Database, 1985 to August 2015) and the China Biological Medicine Database (CBM-disc 1979 to August 2015). We searched reference lists, relevant clinical trials and research registers and contacted pharmaceutical companies and researchers in an effort to identify further published and unpublished studies. Randomised controlled trials (RCTs) or quasi-randomised controlled clinical trials comparing puerarin with placebo or open control (no placebo) in people with ischaemic stroke. Two review authors independently applied the inclusion criteria, assessed trial quality and risk of bias, and extracted the data. We included 20 RCTs with 1574 participants in this updated review. All trials were published in Chinese language journals. We included 14 trials that we had excluded in the previous version of the review after we added a new outcome in this update. Time windows within which the participants were randomised ranged from 4.5 hours to 10 days. Ischaemic stroke was confirmed by computerised tomography (CT) or magnetic resonance imaging (MRI) in 18 trials. Meta-analysis of two trials with 164 participants showed that treatment with puerarin did not reduce death or dependency at final follow-up (RR 0.79, 95% CI 0.45 to 1.36). One trial with 83 participants reported that the mean value of the Barthel Index in the puerarin group was below that in the control group. Meta-analysis of 16 trials with 1305 participants showed that puerarin reduced the proportion of participants without improvement of neurological deficit at the end of follow-up (RR 0.42, 95% CI 0.33 to 0.55). None of the included trials reported serious adverse effects.The quality of evidence was low due to incomplete reporting of the methods and short-term follow-up. There is not enough evidence to evaluate the effect of puerarin on survival or dependency in people with ischaemic stroke. High quality and large-scale RCTs with long-term follow-up are needed to assess its efficacy.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 113 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 23%
Student > Master 18 16%
Student > Bachelor 11 10%
Other 7 6%
Student > Ph. D. Student 6 5%
Other 16 14%
Unknown 29 26%
Readers by discipline Count As %
Medicine and Dentistry 42 37%
Nursing and Health Professions 10 9%
Biochemistry, Genetics and Molecular Biology 5 4%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Neuroscience 4 4%
Other 12 11%
Unknown 36 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2016.
All research outputs
of 25,457,858 outputs
Outputs from Cochrane database of systematic reviews
of 11,499 outputs
Outputs of similar age
of 312,232 outputs
Outputs of similar age from Cochrane database of systematic reviews
of 231 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,499 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.0. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
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