Antidepressants effective? From a Cochrane review: NNT for SSRIs = 7 (fantastic compared to statins, but 6 in 7 people derive no benefit.) NNH = 20 - 90 🤔 https://t.co/W2zbr6HwD2 If we want to reduce demand on overstretched MH services, do something abou
@RachelQuilty @abcnews They also prevent people killing themselves. Not true what you say about studies. The Opposite: https://t.co/QZznQMUzwf (free access) Monthly PBS generic antidepressants are cheaper than 3 coffees. Your statement is a dangerous li
Antidepressants versus placebo for depression in primary care https://t.co/Es358FiKZr
Antidepressants versus placebo for depression in primary care https://t.co/Es358FjiOZ
@david_colquhoun @hannahdev Does it make sense to say, as the article does, that trials collectively show around two-thirds of patients benefit from SSRIs, when the number needed to treat for them (based on those trials) has been found to be 7-8? https://
Antidepressants versus placebo for depression in primary care https://t.co/mSYza0lnfP
@jruokoko @aivokirurgi Ei toi cochrane semminkään näytä dumaavan noita placeboksi suoriltaan. Tuossa nyt vaikkapa yksi. https://t.co/bhQF1G9h96
@alex_here_now @acidshill Honestly the replies see weird. A quick search for relevant cochrane reviews yield this: https://t.co/9Q3LpyLJvQ Seems like there's some solid studies out there.
@sh67atPodcast تعقيب بسيط على الحلقة الجميلة: بالواقع أدوية الاكتئاب أظهرت نتائج ممتازة مقارنة بالبلاسيبو ( و ليش كما ذكرت يا عصام انها ما تفرق كثير) https://t.co/9ydcjciSA0 https://t.co/Ev32CndMHz
@DvlDog0311 @CTCaveman @GraduatedBen https://t.co/nZgVMRsRxI Here's the RCTs
RT @dr_alexharris: Of course, the clinical benefits of antidepressant treatments are not discussed https://t.co/QknbYezdSQ 7/n
@kevsheldrake @RobFlor_ @lynnbixenspan Again this is false. SSRIs and other anti-depressants have been studied against placebos and they are more effective than placebos. They don't work for everyone, but that's not to say they are just a placebo. https:
There been some bad takes re: serotonin and depression, because of a Nature article. While the mechanism may be not fully understood, it’s absolutely wrong to say SSRIs only have a placebo effect. Great thread below.
RT @dr_alexharris: Of course, the clinical benefits of antidepressant treatments are not discussed https://t.co/QknbYezdSQ 7/n
RT @dr_alexharris: Of course, the clinical benefits of antidepressant treatments are not discussed https://t.co/QknbYezdSQ 7/n
Cochrane's r/v of evidence of antidepressant efficacy. Mode of action remains poorly understood. Most (not all) affect monoamines so understandably this has been a research focus. But would we expect mood to correlate with, say, serum 5HT? No, obviously ht
Нарушение в работе серотониновой системы может быть не так уж легко уловить, но мы точно знаем (на больших клинических пострегистрационных исследованиях), что антидепрессанты работают https://t.co/fGyH382hVD
Of course, the clinical benefits of antidepressant treatments are not discussed https://t.co/QknbYezdSQ 7/n
@benzosarebad @atomicaceso Good article to read: https://t.co/PbGP89miq9
@WFrancisEsq @AshleyGWinter Here is a link to a meta-analysis asking the question do SSRI’s exhibit efficacy compared to placebo in primary care offices. https://t.co/itSXmrWfUm
RT @Altostrata: @WeCareAboutMH @fredemag @DrFulli @psychgeist52 @JDaviesPhD #Antidepressants: Cochrane review found "The numbers needed to…
@WeCareAboutMH @fredemag @DrFulli @psychgeist52 @JDaviesPhD #Antidepressants: Cochrane review found "The numbers needed to treat (NNT) are between 6 and 16 for TCAs (median NNT 9) and 7to 8 (median NNT 7) for SSRIs." Arroll, et al. (2009). Antidepressants
@physic22 @The_Nutrivore @whsource Looking at the NNT and NNH for SSRI in a primary care setting, I come to a slightly positive conclusion. https://t.co/ERk6NAHr4w
A eficácia e aceitabilidade dos antidepressivos para o tratamento de pacientes (menores de 65 anos) com depressão atendidos na atenção primária. Confira a tradução: https://t.co/gPUY6chc1U https://t.co/9KeoBLVysG
治療の見かけ上の有効性に対する報告バイアスおよび引用バイアスの累積的な効果:うつ病の例 2018/11 結論:〜 #報告バイアス #引用バイアス の有害な累積効果が示され、#抗うつ薬 の文献から否定的結果が殆ど排除され、公開された少数の否定的結果が発見困難になった。〜 https://t.co/IRzsJBoMUO https://t.co/XvsUPSk4Dj
① その2009年 #コクラン・レビュー は #IPDメタ解析 ではない ② 2010年 #JAMA 掲載 #IPDメタ解析 が重症に対し #NICE 基準で有効性を主張した ③ 2011-18年に #IPDメタ解析 が9件公開され #NICE 基準では1件も有効性を示さず、1件が最重症に対し #プラセボ の優位性を示した https://t.co/KkItjFs26c https://t.co/XBBfo0CeaO
@apetp_ @cescept Antidepresivos tricíclicos e ISRS muestran más eficacia que el placebo en depresión en el ámbito de la atención primaria (no son las más graves, que se ven en psiquiatría). https://t.co/3ssR6fTX4M
『中等症以上の #うつ病 における #抗うつ薬 の有効性を疑う立場はほとんどない[https://t.co/70f8yGaRng, https://t.co/hB1pKtdMQX]。』 #日本うつ病学会 #大うつ病性障害 (#DSM5) #うつ病 治療 #ガイドライン 2016 https://t.co/kbudCy7cNj https://t.co/N81CJkNOeJ
RT @HengartnerMP: @cbt_therapist @CEP_UK Sure. See here https://t.co/T0gKH0H5Y9 and here https://t.co/81mmoq3l5u and here https://t.co/OHYe…
@cbt_therapist @CEP_UK Sure. See here https://t.co/T0gKH0H5Y9 and here https://t.co/81mmoq3l5u and here https://t.co/OHYeKXKxfE
@LBoucherAuthor @maryamigl1 At best, the efficacy of SSRI medication yields a number needed to treat of 8 - meaning 8 people are treated with SSRI antidepressants for 1 to benefit. https://t.co/YujZYgnvdx
@_NatashaDevon @cochranecollab Here you go. Seems like most studies in to them have been funded by pharma though... https://t.co/zghFTsyMgJ
@PhuckSea @ronanOreilly38 @Cobratate Incorrect, unless you'd like to argue with this Cochrane review. https://t.co/f8BDXLTdWT https://t.co/2lIIHPe5a0
@Fiddaman https://t.co/DVtTZ1JXRm a meta analysis by the cochrane institute disagrees.
@Fiddaman @Jet2707 @rcpsych @BBCr4today Did you read my last tweet? Benefit = improved mood. Typically assessed by validated scores. https://t.co/NWLJMVQNeu
@MrMMarsh @GoodThinkingSoc but it's unfathomable. SSRIs work https://t.co/CUJ0yqnKVR and homeopathy doesn't https://t.co/EBKKSsDprW
Antidepressants versus #placebo for #depression in primary care. #CochraneDatabase #pubmed #NCBI... http://t.co/s5Dg6VLr1a
Hey @cochranecollab your review on one of the most common prescript'ns was last assessed current in 2007. Priorities? http://t.co/Umk0Bz3XDf
Hey @cochranecollab your review on one of the most common prescript'ns was last assessed current in 2007. Priorities? http://t.co/Umk0Bz3XDf
Hey @cochranecollab your review on one of the most common prescript'ns was last assessed current in 2007. Priorities? http://t.co/Umk0Bz3XDf
Hey @cochranecollab your review on one of the most common prescript'ns was last assessed current in 2007. Priorities? http://t.co/Umk0Bz3XDf
@DrabsbSandy Cochrane review said antidepressants effective in primary care. http://t.co/IzVhoUHW
@drjamiegreen try this..http://www.ncbi.nlm.nih.gov/pubmed/19588448 ..from Cochrane..