Title |
Tricyclic antidepressants for autism spectrum disorders (ASD) in children and adolescents
|
---|---|
Published in |
Cochrane database of systematic reviews, March 2012
|
DOI | 10.1002/14651858.cd008372.pub2 |
Pubmed ID | |
Authors |
Romy Hurwitz, Roger Blackmore, Philip Hazell, Katrina Williams, Susan Woolfenden |
Abstract |
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders, ranging in severity and characterised by early onset of delay and deviance in the development of social interaction, and verbal and nonverbal communication. ASD is associated with restricted and/or stereotyped interests or behaviours. Tricyclic antidepressants (TCAs) block noradrenaline and serotonin reuptake, increasing the availability of these neurotransmitters in the central nervous system. Via their impact on serotonin, TCAs have been used in the treatment of autistic symptoms and comorbidities in individuals with ASD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 57% |
Sweden | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | <1% |
Netherlands | 1 | <1% |
South Africa | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 358 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 64 | 18% |
Researcher | 41 | 11% |
Student > Ph. D. Student | 35 | 10% |
Student > Postgraduate | 30 | 8% |
Student > Bachelor | 30 | 8% |
Other | 69 | 19% |
Unknown | 95 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 108 | 30% |
Psychology | 45 | 12% |
Nursing and Health Professions | 25 | 7% |
Social Sciences | 17 | 5% |
Neuroscience | 12 | 3% |
Other | 50 | 14% |
Unknown | 107 | 29% |