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Cochrane Database of Systematic Reviews

Cell salvage for minimising perioperative allogeneic blood transfusion

Overview of attention for article published in Cochrane database of systematic reviews, April 2010
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Mentioned by

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2 X users
wikipedia
1 Wikipedia page

Citations

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174 Dimensions

Readers on

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326 Mendeley
Title
Cell salvage for minimising perioperative allogeneic blood transfusion
Published in
Cochrane database of systematic reviews, April 2010
DOI 10.1002/14651858.cd001888.pub4
Pubmed ID
Authors

Paul A Carless, David A Henry, Annette J Moxey, Dianne O'Connell, Tamara Brown, Dean A Fergusson

Abstract

Concerns regarding the safety of transfused blood have prompted reconsideration of the use of allogeneic (from an unrelated donor) red blood cell (RBC) transfusion, and a range of techniques to minimise transfusion requirements. To examine the evidence for the efficacy of cell salvage in reducing allogeneic blood transfusion and the evidence for any effect on clinical outcomes. We identified studies by searching CENTRAL (The Cochrane Library 2009, Issue 2), MEDLINE (1950 to June 2009), EMBASE (1980 to June 2009), the internet (to August 2009) and bibliographies of published articles. Randomised controlled trials with a concurrent control group in which adult patients, scheduled for non-urgent surgery, were randomised to cell salvage (autotransfusion) or to a control group who did not receive the intervention. Data were independently extracted and the risk of bias assessed. Relative risks (RR) and weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated. Data were pooled using a random-effects model. The primary outcomes were the number of patients exposed to allogeneic red cell transfusion and the amount of blood transfused. Other clinical outcomes are detailed in the review. A total of 75 trials were included. Overall, the use of cell salvage reduced the rate of exposure to allogeneic RBC transfusion by a relative 38% (RR 0.62; 95% CI 0.55 to 0.70). The absolute reduction in risk (ARR) of receiving an allogeneic RBC transfusion was 21% (95% CI 15% to 26%). In orthopaedic procedures the RR of exposure to RBC transfusion was 0.46 (95% CI 0.37 to 0.57) compared to 0.77 (95% CI 0.69 to 0.86) for cardiac procedures. The use of cell salvage resulted in an average saving of 0.68 units of allogeneic RBC per patient (WMD -0.68; 95% CI -0.88 to -0.49). Cell salvage did not appear to impact adversely on clinical outcomes. The results suggest cell salvage is efficacious in reducing the need for allogeneic red cell transfusion in adult elective cardiac and orthopaedic surgery. The use of cell salvage did not appear to impact adversely on clinical outcomes. However, the methodological quality of trials was poor. As the trials were unblinded and lacked adequate concealment of treatment allocation, transfusion practices may have been influenced by knowledge of the patients' treatment status potentially biasing the results in favour of cell salvage.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 326 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Australia 2 <1%
Italy 1 <1%
Netherlands 1 <1%
Germany 1 <1%
United Kingdom 1 <1%
South Africa 1 <1%
Spain 1 <1%
Canada 1 <1%
Other 0 0%
Unknown 313 96%

Demographic breakdown

Readers by professional status Count As %
Other 42 13%
Student > Master 39 12%
Student > Bachelor 36 11%
Researcher 35 11%
Student > Postgraduate 32 10%
Other 77 24%
Unknown 65 20%
Readers by discipline Count As %
Medicine and Dentistry 174 53%
Nursing and Health Professions 23 7%
Engineering 8 2%
Agricultural and Biological Sciences 6 2%
Psychology 6 2%
Other 36 11%
Unknown 73 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2017.
All research outputs
#7,116,428
of 25,576,801 outputs
Outputs from Cochrane database of systematic reviews
#8,694
of 13,155 outputs
Outputs of similar age
#32,669
of 103,146 outputs
Outputs of similar age from Cochrane database of systematic reviews
#45
of 79 outputs
Altmetric has tracked 25,576,801 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 13,155 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.8. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,146 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.