| Title |
Glutamine supplementation to prevent morbidity and mortality in preterm infants
|
|---|---|
| Published in |
Cochrane database of systematic reviews, April 2016
|
| DOI | 10.1002/14651858.cd001457.pub6 |
| Pubmed ID | |
| Authors |
Thirimon Moe‐Byrne, Jennifer VE Brown, William McGuire |
| Abstract |
Glutamine is a conditionally essential amino acid. Endogenous biosynthesis may be insufficient for tissue needs in states of metabolic stress. Evidence exists that glutamine supplementation improves clinical outcomes in critically ill adults. It has been suggested that glutamine supplementation may also benefit preterm infants. To determine the effects of glutamine supplementation on mortality and morbidity in preterm infants. We used the standard search strategy of the Cochrane Neonatal Review Group. This included searches of the Cochrane Central Register of Controlled Trials (CENTRAL, 2015, Issue 12), MEDLINE, EMBASE and Maternity and Infant Care (to December 2015), conference proceedings and previous reviews. Randomised or quasi-randomised controlled trials that compared glutamine supplementation versus no glutamine supplementation in preterm infants at any time from birth to discharge from hospital. We extracted data using the standard methods of the Cochrane Neonatal Review Group, with separate evaluation of trial quality and data extraction by two review authors. We synthesised data using a fixed-effect model and reported typical relative risk, typical risk difference and weighted mean difference. We identified 12 randomised controlled trials in which a total of 2877 preterm infants participated. Six trials assessed enteral glutamine supplementation and six trials assessed parenteral glutamine supplementation. The trials were generally of good methodological quality. Meta-analysis did not find an effect of glutamine supplementation on mortality (typical relative risk 0.97, 95% confidence interval 0.80 to 1.17; risk difference 0.00, 95% confidence interval -0.03 to 0.02) or major neonatal morbidities including the incidence of invasive infection or necrotising enterocolitis. Three trials that assessed neurodevelopmental outcomes in children aged 18 to 24 months and beyond did not find any effects. The available trial data do not provide evidence that glutamine supplementation confers important benefits for preterm infants. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 42% |
| Brazil | 1 | 8% |
| Venezuela, Bolivarian Republic of | 1 | 8% |
| Canada | 1 | 8% |
| Unknown | 4 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 67% |
| Practitioners (doctors, other healthcare professionals) | 3 | 25% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 265 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 263 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 37 | 14% |
| Student > Bachelor | 36 | 14% |
| Researcher | 30 | 11% |
| Other | 14 | 5% |
| Student > Postgraduate | 14 | 5% |
| Other | 49 | 18% |
| Unknown | 85 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 75 | 28% |
| Nursing and Health Professions | 32 | 12% |
| Unspecified | 13 | 5% |
| Social Sciences | 10 | 4% |
| Biochemistry, Genetics and Molecular Biology | 10 | 4% |
| Other | 31 | 12% |
| Unknown | 94 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2024.
All research outputs
#1,287,828
of 25,457,297 outputs
Outputs from Cochrane database of systematic reviews
#2,721
of 11,499 outputs
Outputs of similar age
#21,644
of 313,715 outputs
Outputs of similar age from Cochrane database of systematic reviews
#81
of 241 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,499 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.0. This one has done well, scoring higher than 77% of its peers.
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