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Cochrane Database of Systematic Reviews

Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer

Overview of attention for article published in Cochrane database of systematic reviews, August 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
4 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
76 Mendeley
Title
Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer
Published in
Cochrane database of systematic reviews, August 2012
DOI 10.1002/14651858.cd007814.pub2
Pubmed ID
Authors

Sanjeev Deva, Michael Jameson

Abstract

Anecdotal reports of tumour regression with histamine type 2 receptor antagonists (H(2)RAs) have lead to a series of trials with this class of drug as adjuvant therapy to try and improve outcomes in patients with resected colorectal cancers. There was a plausible scientific rationale suggesting merit in this strategy. This included improved immune surveillance (by way of increasing tumour infiltrating lymphocytes), inhibiting the direct proliferative effect of histamine as a growth factor for colorectal cancer and, in the case of cimetidine, inhibiting endothelial expression of E-selectin (a cell adhesion molecule thought to be critical for metastatic spread).

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 1%
Unknown 75 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 20%
Student > Ph. D. Student 10 13%
Student > Master 10 13%
Student > Bachelor 7 9%
Other 5 7%
Other 10 13%
Unknown 19 25%
Readers by discipline Count As %
Medicine and Dentistry 31 41%
Nursing and Health Professions 9 12%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Engineering 2 3%
Economics, Econometrics and Finance 2 3%
Other 5 7%
Unknown 23 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2020.
All research outputs
#4,039,889
of 16,547,829 outputs
Outputs from Cochrane database of systematic reviews
#6,522
of 11,527 outputs
Outputs of similar age
#30,631
of 138,079 outputs
Outputs of similar age from Cochrane database of systematic reviews
#44
of 85 outputs
Altmetric has tracked 16,547,829 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,527 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.4. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 138,079 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.